MATERIALSAND METHODS All chemicals were reagent grade. Na'25], as a solution in NI
10 NaOH, was purchased from the Edmonton Radiopharmacy Center. Solvents were …

α‐D‐(5‐Fluoro‐5‐deoxyarabinofuranosyl)‐2‐nitroimidazole (fluoroazomycin arabinoside,
FAZA) 6, a putative PET imaging agent when labelled with 18F, was synthesized by …

Misonidazole (MISO), a selective radiosensitizer of hypoxic cells, forms adducts with cellular
biomolecules with rates which are 30-50× higher under hypoxic as compared to aerobic …

Non-invasive predictive assays which can confirm the presence or absence of hypoxic cells
in human tumours show promise for understanding the natural history of tumour …

Seven second‐generation hypoxic markers of the iodinated azomycin nucleoside class
have been synthesized and tested for hypoxia marking activity with tumor cells in vitro and in …

Second-generation nuclear medicine markers of tumour hypoxia have been synthesised
and screened for hypoxic marking activity in cell cultures and in mouse tumours (EMT-6) …

Misonidazole is a known hypoxic cell sensitizer that binds covalently in hypoxic cells. Its
congenerslabeledwith 77Br, 75Br, or 18F, are likelycandidatesfor imaginghypoxia. We have …

Methods: Accumulationof BMS181321 was studied inaerobic and hypoxic (< 10 PPM O2)
suspension cultures of Chinese hamster ovary (CHO) cells at 37ĀCand the oxygen …

Tumour oxygenation status in individual patients may be assessed using the bioreduction
and linkage of 2-nitroimidazole markers to viable hypoxic cells in vivo with subsequent …

RO-07-0582 toxicity studies were performed in 12 patients for a total of 16 assays. Single
and multifraction dose schedules were used, and drug concentrations in solid tumor tissue …