PET with 18F-labeled arginine-glycine-aspartic acid (RGD) peptides can visualize and
quantify ανβ3 integrin expression in patients, but radiolabeling is complex and image …

Integrin αvβ3 plays a critical role in tumor angiogenesis and metastasis. Suitably
radiolabeled cyclic arginine-glycine-aspartic (RGD) peptides can be used for noninvasive …

The αv-integrins, cell adhesion molecules that are highly expressed on activated endothelial
cells and tumor cells but not on dormant endothelial cells or normal cells, present an …

Purpose RGD peptide-based radiotracers are well established as integrin α v β 3 imaging
probes to evaluate tumor angiogenesis or tissue remodeling after ischemia or infarction. In …

Over the last years Gallium-68 (68 Ga) has received tremendous attention for labeling of
radiopharmaceuticals for positron emission tomography (PET). 68 Ga labeling of …

The integrin αvβ3 receptor is upregulated on tumor cells and endothelium and plays
important roles in angiogenesis and metastasis. Arg-Gly-Asp (RGD) peptide ligands have …

Purpose We and others have reported that 18 F-and 64 Cu-labeled arginine–glycine–
aspartate (RGD) peptides allow positron emission tomography (PET) quantification of …

OBJECTIVES: The αvβ3 integrin is a cell adhesion molecule known to be involved in stages
of angiogenesis and metastasis. In this study, the chelators CB-TE2A and diamsar were …

Purpose One of the major obstacles of the clinical translation of 18 F-labeled arginine-
glycine-aspartic acid (RGD) peptides has been the laborious multistep radiosynthesis. In …

Expression of the cellular transmembrane receptor αvβ6 integrin is essentially restricted to
malignant epithelial cells in carcinomas of a broad variety of lineages, whereas it is virtually …