[PDF][PDF] A comparison of EGF and MAb 528 labeled with 111In for imaging human breast cancer
RM Reilly, R Kiarash, J Sandhu, YW Lee… - Journal of Nuclear …, 2000 - Soc Nuclear Med
Division ofNuclear Medicine and Departments ofPathology and Radiation Oncology,
Toronto General HospitaL/Princess Margaret Hospital, University Health Network, Toronto; …
Toronto General HospitaL/Princess Margaret Hospital, University Health Network, Toronto; …
[PDF][PDF] 111In-labeled EGF is selectively radiotoxic to human breast cancer cells overexpressing EGFR
RM Reilly, R Kiarash, RG Cameron… - Journal of Nuclear …, 2000 - Soc Nuclear Med
Overexpression of the epidermal growth factor (EGF) receptor (EGFR) at levels up to 100
times higher than that observed on normal epithelial cells has been observed in 30% — …
times higher than that observed on normal epithelial cells has been observed in 30% — …
A kit formulated under good manufacturing practices for labeling human epidermal growth factor with 111In for radiotherapeutic applications
RM Reilly, DA Scollard, J Wang, H Mondal… - Journal of Nuclear …, 2004 - Soc Nuclear Med
Our goal was to design and manufacture a kit under good manufacturing practices (GMP) for
the preparation of 111In-DTPA-hEGF Injection, a novel targeted radiotherapeutic agent for …
the preparation of 111In-DTPA-hEGF Injection, a novel targeted radiotherapeutic agent for …
A new radioligand for the epidermal growth factor receptor: 111In-labeled human epidermal growth factor derivatized with a bifunctional metal-chelating peptide
S Remy, RM Reilly, K Sheldon… - Bioconjugate chemistry, 1995 - ACS Publications
Breast cancer represents a major cause of mortality in North American women with more
than 40 000 deaths reported in 1994 alone (1). The epithelial cells of the breast are under …
than 40 000 deaths reported in 1994 alone (1). The epithelial cells of the breast are under …
Antitumor effects and normal tissue toxicity of 111In-labeled epidermal growth factor administered to athymic mice bearing epidermal growth factor receptor-positive …
P Chen, R Cameron, J Wang, KA Vallis… - Journal of nuclear …, 2003 - Soc Nuclear Med
The epidermal growth factor receptor (EGFR) is an attractive target for the design of
radiotherapeutic agents for breast cancer because it is present on almost all estrogen …
radiotherapeutic agents for breast cancer because it is present on almost all estrogen …
Imaging of EGFR expression in murine xenografts using site-specifically labelled anti-EGFR 111In-DOTA-ZEGFR:2377 Affibody molecule: aspect of the injected …
V Tolmachev, D Rosik, H Wållberg, A Sjöberg… - European journal of …, 2010 - Springer
Introduction Overexpression of epidermal growth factor receptor (EGFR) is a prognostic and
predictive biomarker in a number of malignant tumours. Radionuclide molecular imaging of …
predictive biomarker in a number of malignant tumours. Radionuclide molecular imaging of …
Factors influencing the sensitivity of tumor imaging with a receptor-binding radiopharmaceutical
The overexpression of cell surface receptors on cancer cells is a potential target for the
design of receptor-binding radiopharmaceuticals for tumor imaging. The sensitivity of these …
design of receptor-binding radiopharmaceuticals for tumor imaging. The sensitivity of these …
Molecular imaging of HER2-expressing malignant tumors in breast cancer patients using synthetic 111In-or 68Ga-labeled affibody molecules
The clinical utility of a human epidermal growth factor receptor 2 (HER2)–targeting Affibody
molecule for detection and characterization of HER2-positive lesions was investigated in …
molecule for detection and characterization of HER2-positive lesions was investigated in …
[HTML][HTML] Phase I trial to evaluate the tumor and normal tissue uptake, radiation dosimetry and safety of 111In-DTPA-human epidermal growth factor in patients with …
KA Vallis, RM Reilly, D Scollard, P Merante… - American journal of …, 2014 - ncbi.nlm.nih.gov
The safety, pharmacokinetics, biodistribution and radiation dosimetry of 111 In-DTPA-hEGF,
an Auger electron-emitting radiopharmaceutical, were evaluated in a first-in-human trial …
an Auger electron-emitting radiopharmaceutical, were evaluated in a first-in-human trial …
In vivo and in vitro uptake of 111In, delivered with the affibody molecule (ZEGFR: 955) 2, in EGFR expressing tumour cells
E Nordberg, A Orlova, M Friedman… - Oncology …, 2008 - spandidos-publications.com
The epidermal growth factor receptor, EGFR, is overexpressed in many carcinomas.
Targeting this receptor with radionuclides is important for imaging and therapy applications …
Targeting this receptor with radionuclides is important for imaging and therapy applications …
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