The Characteristics of I-125 4-IQNB and H-3 QNB In Vivo and In Vitro Page 1
BASICSCIENCES The muscarinic acetylcholine receptor (m-AChR) is present in the heart (1—3),pancreas …

MATERIALS AND METHODS Isomerically pure tri-n-butylstannyl-QNB precursors of the four
[I23I] IQNB stereoisomers (Fig. 1) were prepared in ad vance and their structure and …

MATERIALS AND METHODS All radioiodinated ligands were prepared according to the
method of Rzeszotarski et al.(1). The iodinated QNB analog (4.4125!] IQNB) was …

In Vitro and In Vivo Characteristics (S)-4-Iodobenzilate Page 1 -Quinuclidinyl 4-iodobenzilate
(4IQNB: Fig. 1)is a high affinity muscarinic acetylcholine receptor (m AChR) antagonist. It has …

MATERIALS AND METHODS Our studies on the synthesis of 4-IAP (1-131) from Na'31I used
4 mg of 4-IAP, or 10 mg of 4-BrAP, with heating at acid pH in a boiling water bath. Optimal …

METHODS Preparation of In-i 11oxine. For the first five prepa rations, In-I 11oxine was
supplied commercially.* For the subsequent four studies In-i 11oxine was prepared as …

RenalClearanceandExtractionParametersof ortho-iodohippurate(I-123) ComparedwithOIH(l-.131)andPAH
Page 1 Iodine-I23 has almost ideal radionuclidic properties for in vivo diagnostic procedures …

The effect of a chelator structure on the metabolic fate of the 111ln-labeledmonoclonal
antibody (Mab) T101 was investigated in normal Balb/c mice to assess the importance of this …

Iodine-123 is an ideal radioiodine for use in radiopharmaceuticals. The desirability of
123Ifrom the point of view of its physical properties and radiation dosimetry is well known …

Synthesisand BiologicalEvaluationof Tc-99m N,N'-Bis(mercaptoacetyl)-2,3- diaminopropanoate:A
PotentialReplacementfor [1 @ 11]oi Page 1 BASICSCIENCES In 1979 Davison and co-workers (1) …