Biodistribution and radiation dosimetry of 11C-WAY100, 635 in humans
RV Parsey, MJ Belanger, GM Sullivan… - Journal of Nuclear …, 2005 - Soc Nuclear Med
Serotonin 1A receptors have been implicated in a variety of conditions including depression,
suicidal behavior, and aggression. Dose estimates for current human studies are based on …
suicidal behavior, and aggression. Dose estimates for current human studies are based on …
In vivo quantification of human serotonin 1A receptor using 11C-CUMI-101, an agonist PET radiotracer
MS Milak, C DeLorenzo, F Zanderigo… - Journal of Nuclear …, 2010 - Soc Nuclear Med
The serotonin (5-hydroxytryptamine, or 5-HT) type 1A receptor (5-HT1AR) is implicated in
the pathophysiology of numerous neuropsychiatric disorders. We have published the initial …
the pathophysiology of numerous neuropsychiatric disorders. We have published the initial …
11C-CUMI-101, a PET radioligand, behaves as a serotonin 1A receptor antagonist and also binds to α1 adrenoceptors in brain
SS Shrestha, JS Liow, S Lu, K Jenko… - Journal of Nuclear …, 2014 - Soc Nuclear Med
The PET radioligand 11C-CUMI-101 was previously suggested as a putative agonist
radioligand for the serotonin 1A (5-hydroxytryptamine 1A [5-HT1A]) receptor in recombinant …
radioligand for the serotonin 1A (5-hydroxytryptamine 1A [5-HT1A]) receptor in recombinant …
Modeling considerations for 11C-CUMI-101, an agonist radiotracer for imaging serotonin 1A receptor in vivo with PET
Several lines of evidence demonstrate involvement of serotonin 1A receptors (5-HT1ARs) in
the pathophysiology of neuropsychiatric disorders such as depression, suicidal behavior …
the pathophysiology of neuropsychiatric disorders such as depression, suicidal behavior …
First-in-human evaluation of 18F-mefway, a PET radioligand specific to serotonin-1A receptors
AT Hillmer, DW Wooten, AK Bajwa… - Journal of Nuclear …, 2014 - Soc Nuclear Med
The serotonin-1A (5-HT1A; 5-HT is 5-hydroxytryptamine) receptor is implicated in an array of
neurologic and psychiatric disorders. Current PET radioligands targeting 5-HT1A receptors …
neurologic and psychiatric disorders. Current PET radioligands targeting 5-HT1A receptors …
In vivo evaluation of 18F-MNI698: an 18F-labeled radiotracer for imaging of serotonin 4 receptors in brain
AAS Tavares, F Caillé, O Barret, C Papin… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Serotonin 4 receptors (5-hydroxytryptamine receptor 4 [5HT4R]) hold promise as a novel
therapeutic approach to multiple brain disorders, including Alzheimer and Huntington …
therapeutic approach to multiple brain disorders, including Alzheimer and Huntington …
Whole-body biodistribution and dosimetry estimates of a novel radiotracer for imaging of serotonin 4 receptors in brain:[18F] MNI-698
AAS Tavares, F Caillé, O Barret, C Papin, H Lee… - Nuclear Medicine and …, 2014 - Elsevier
Introduction A new radiotracer for imaging the serotonin 4 receptors (5-HT 4) in brain,[18 F]
MNI-698, was recently developed by our group. Evaluation in nonhuman primates indicates …
MNI-698, was recently developed by our group. Evaluation in nonhuman primates indicates …
[HTML][HTML] Human Biodistribution and Dosimetry of 11C-CUMI-101, an Agonist Radioligand for Serotonin-1A Receptors in Brain
CS Hines, JS Liow, P Zanotti-Fregonara, J Hirvonen… - PLoS …, 2011 - journals.plos.org
As a reported agonist, 11C-CUMI-101 is believed to selectively bind the G-protein-coupled
state of the serotonin-1A (5-HT1A) receptor, thereby providing a measure of the active …
state of the serotonin-1A (5-HT1A) receptor, thereby providing a measure of the active …
High-resolution imaging of brain 5-HT1B receptors in the rhesus monkey using [11C] P943
The serotonin 5-HT1B receptors regulate the release of serotonin and are involved in
various disease states, including depression and schizophrenia. The goal of the study was …
various disease states, including depression and schizophrenia. The goal of the study was …
Quantitative Analysis of [11C]AZ10419369 Binding to 5-HT1B Receptors in Human Brain
K Varnäs, S Nyberg, C Halldin… - Journal of Cerebral …, 2011 - journals.sagepub.com
A novel radioligand for positron emission tomography (PET) imaging of serotonin 5-HT1B
receptors,[11C] AZ10419369, has been recently described. In this study, the potential for …
receptors,[11C] AZ10419369, has been recently described. In this study, the potential for …