Revisit to Radiomethylation of [11C] MeNER: Optimization and Improved automated loop radiosynthesis of PET radiopharmaceutical [11C] MeNER for norepinephrine …
R Neelamegam, D Yokell, P Rice, G El Fakhri… - 2018 - Soc Nuclear Med
668 Objectives:(S, S)-[11 C] MeNER also known as (S, S)-[11 C] methylreboxetine or (S, S)-
[11 C] MRB, has been considered a candidate radioligand for imaging brain norepinephrine …
[11 C] MRB, has been considered a candidate radioligand for imaging brain norepinephrine …
Synthesis, radiosynthesis and evaluation of (S, R)-and (R, S)-[11C] EPMMI as norepinephrine transporter imaging agents
F Zeng, A Smith, R Voll, M Goodman - 2012 - Soc Nuclear Med
1617 Objectives Among several other evaluated radioligands,(S, S)-[11 C] MeNER and (S,
S)-[18 F] FMeNER-D 2, analogs of reboxetine, show the best properties for imaging NET in …
S)-[18 F] FMeNER-D 2, analogs of reboxetine, show the best properties for imaging NET in …
Radiosynthesis and microPET evaluation of (S, S)-6-F-[11C] methylreboxetine and (S, S)-3-F-[11C] methylreboxetine as norepinephrine transporter imaging agents
F Zeng, J Mun, J Nye, W Yu, R Voll, L Howell… - 2014 - Soc Nuclear Med
1817 Objectives Attempts to image the norepinephrine transporter (NET) in living systems
with PET have so far met with limited success due to the lack of effective radioligands.(S, S) …
with PET have so far met with limited success due to the lack of effective radioligands.(S, S) …
[11C] NS8880, a promising PET radiotracer targeting the norepinephrine transporter
KH Vase, D Peters, EØ Nielsen, AKO Alstrup… - Nuclear Medicine and …, 2014 - Elsevier
Introduction Positron emission tomography (PET) imaging of the norepinephrine transporter
(NET) is still hindered by the availability of useful PET imaging probes. The present study …
(NET) is still hindered by the availability of useful PET imaging probes. The present study …
18F-Labeled analogs of reboxetine as PET imaging agents for norepinephrine transporters
F Zeng, N Jarkas, J Stehouwer, L Williams, J Votaw… - 2007 - Soc Nuclear Med
1335 Objectives: The development of radioligands to map the norepinephrine transporter
(NET) by positron emission tomography (PET) techniques presents unique opportunities to …
(NET) by positron emission tomography (PET) techniques presents unique opportunities to …
Synthesis and evaluation of a C-11 labeled reboxetine analog as a norepinephrine transporter imaging agent
F Zeng, N Jarkas, J Stehouwer, R Voll, M Owens… - 2006 - Soc Nuclear Med
1821 Objectives: The norepinephrine transporter (NET), a specific marker of noradrenergic
neurons, has been recognized in the involvement of several neurological and psychiatric …
neurons, has been recognized in the involvement of several neurological and psychiatric …
Radiosynthesis and microPET evaluation of (S, R)-[11C] EPMMI and (S)-[11C] FDBMB as norepinephrine transporter imaging agents
F Zeng, R Voll, A Smith, L Williams, M Goodman - 2013 - Soc Nuclear Med
1751 Objectives Attempts to image the norepinephrine transporter (NET) in living systems
with PET have so far met with limited success due to the lack of effective radioligands.(S, R) …
with PET have so far met with limited success due to the lack of effective radioligands.(S, R) …
Investigation of the Metabolites of (S,S)-[11C]MeNER in Humans, Monkeys and Rats
Abstract Introduction (S, S)-[11 C] MeNER ((S, S)-2-(α-(2-[11 C] methoxyphenoxy) benzyl)
morpholine) is a positron emission tomography (PET) radioligand recently applied in clinical …
morpholine) is a positron emission tomography (PET) radioligand recently applied in clinical …
Synthesis and evaluation of (S, S)-[11C] SMENET as a norepinephrine transporter imaging agent
F Zeng, J Mun, N Jarkas, J Stehouwer, R Voll… - 2008 - Soc Nuclear Med
1215 Objectives: Previously reported NET imaging agent,(S, S)-[11 C] MeNER, displayed a
high binding affinity and selectivity towards NET in vivo. However, specific binding to NET …
high binding affinity and selectivity towards NET in vivo. However, specific binding to NET …
Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter
F Zeng, N Jarkas, JS Stehouwer, RJ Voll… - Bioorganic & medicinal …, 2008 - Elsevier
Six new (S, S)-enantiomers of reboxetine derivatives were synthesized and their binding
affinities were determined via competition binding assays in cells expressing the human …
affinities were determined via competition binding assays in cells expressing the human …