Diels–Alder reaction for tumor pretargeting: in vivo chemistry can boost tumor radiation dose compared with directly labeled antibody
R Rossin, T Läppchen… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Current pretargeting systems use noncovalent biologic interactions, which are prone to
immunogenicity. We previously developed a novel approach based on the bioorthogonal …
immunogenicity. We previously developed a novel approach based on the bioorthogonal …
Trans-Cyclooctene Tag with Improved Properties for Tumor Pretargeting with the Diels–Alder Reaction
R Rossin, SMJ van Duijnhoven… - Molecular …, 2014 - ACS Publications
Radioimmunotherapy (RIT) of solid tumors is hampered by low tumor-to-nontumor (T/NT)
ratios of the radiolabeled monoclonal antibodies resulting in low tumor doses in patients …
ratios of the radiolabeled monoclonal antibodies resulting in low tumor doses in patients …
[HTML][HTML] Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models
O Keinänen, K Fung, J Pourat, V Jallinoja, D Vivier… - EJNMMI research, 2017 - Springer
Background Pretargeting-based approaches are being investigated for
radioimmunoimaging and therapy applications to reduce the effective radiation burden to …
radioimmunoimaging and therapy applications to reduce the effective radiation burden to …
Diabody pretargeting with click chemistry in vivo
SMJ van Duijnhoven, R Rossin… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Radioimmunotherapy and nuclear imaging (immuno-PET/SPECT) of cancer with radiometal-
labeled antibody fragments or peptides is hampered by low tumor-to-kidney ratios because …
labeled antibody fragments or peptides is hampered by low tumor-to-kidney ratios because …
Establishment of the In Vivo Efficacy of Pretargeted Radioimmunotherapy Utilizing Inverse Electron Demand Diels-Alder Click Chemistry
JL Houghton, R Membreno, D Abdel-Atti… - Molecular cancer …, 2017 - AACR
The pretargeting system based on the inverse electron demand Diels-Alder reaction
(IEDDA) between trans-cyclooctene (TCO) and tetrazine (Tz) combines the favorable …
(IEDDA) between trans-cyclooctene (TCO) and tetrazine (Tz) combines the favorable …
A pretargeted PET imaging strategy based on bioorthogonal Diels–Alder click chemistry
The specificity of antibodies have made immunoconjugates promising vectors for the
delivery of radioisotopes to cancer cells; however, their long pharmacologic half-lives …
delivery of radioisotopes to cancer cells; however, their long pharmacologic half-lives …
DOTA-tetrazine probes with modified linkers for tumor pretargeting
T Läppchen, R Rossin, TR van Mourik, G Gruntz… - Nuclear medicine and …, 2017 - Elsevier
Introduction Pretargeted radioimmunoimaging and-therapy approaches building on the
bioorthogonal inverse-electron-demand Diels–Alder (IEDDA) reaction between strained …
bioorthogonal inverse-electron-demand Diels–Alder (IEDDA) reaction between strained …
Antibody pretargeting based on bioorthogonal click chemistry for cancer imaging and targeted radionuclide therapy
A Rondon, F Degoul - Bioconjugate Chemistry, 2019 - ACS Publications
Bioorthogonal click chemistry—employing antibody-conjugated trans-cyclooctenes (TCO)
and tetrazine (Tz)-based radioligands able to covalently bind in vivo—appeared recently as …
and tetrazine (Tz)-based radioligands able to covalently bind in vivo—appeared recently as …
Feasibility of affibody-based bioorthogonal chemistry–mediated radionuclide pretargeting
M Altai, A Perols, M Tsourma, B Mitran… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Affibody molecules constitute a new class of probes for radionuclide tumor targeting. The
small size of Affibody molecules is favorable for rapid localization in tumors and clearance …
small size of Affibody molecules is favorable for rapid localization in tumors and clearance …
Metal-free cycloaddition chemistry driven pretargeted radioimmunotherapy using α-particle radiation
The pretargeted radioimmunotherapy approach (PRIT) decouples the administration of
tumor targeting monoclonal antibodies (mAbs) from that of the radiolabeled ligand. This …
tumor targeting monoclonal antibodies (mAbs) from that of the radiolabeled ligand. This …