Current pretargeting systems use noncovalent biologic interactions, which are prone to
immunogenicity. We previously developed a novel approach based on the bioorthogonal …

Radioimmunotherapy (RIT) of solid tumors is hampered by low tumor-to-nontumor (T/NT)
ratios of the radiolabeled monoclonal antibodies resulting in low tumor doses in patients …

Background Pretargeting-based approaches are being investigated for
radioimmunoimaging and therapy applications to reduce the effective radiation burden to …

Radioimmunotherapy and nuclear imaging (immuno-PET/SPECT) of cancer with radiometal-
labeled antibody fragments or peptides is hampered by low tumor-to-kidney ratios because …

The pretargeting system based on the inverse electron demand Diels-Alder reaction
(IEDDA) between trans-cyclooctene (TCO) and tetrazine (Tz) combines the favorable …

The specificity of antibodies have made immunoconjugates promising vectors for the
delivery of radioisotopes to cancer cells; however, their long pharmacologic half-lives …

Introduction Pretargeted radioimmunoimaging and-therapy approaches building on the
bioorthogonal inverse-electron-demand Diels–Alder (IEDDA) reaction between strained …

Bioorthogonal click chemistry—employing antibody-conjugated trans-cyclooctenes (TCO)
and tetrazine (Tz)-based radioligands able to covalently bind in vivo—appeared recently as …

Affibody molecules constitute a new class of probes for radionuclide tumor targeting. The
small size of Affibody molecules is favorable for rapid localization in tumors and clearance …

The pretargeted radioimmunotherapy approach (PRIT) decouples the administration of
tumor targeting monoclonal antibodies (mAbs) from that of the radiolabeled ligand. This …