1141 Objectives: Until recently, passive diffusion across the BBB has been a general
assumption for transport of PET radioligands into the brain. To account for active transport …

Translocator protein (TSPO)(18 kDa), formerly called the peripheral benzodiazepine
receptor, is upregulated on activated microglia and macrophages and is, thus, a biomarker …

A good understanding of the in vivo pharmacokinetics of radioligands is important for
accurate PET quantification in molecular brain imaging. For many reversibly binding …

334 Objectives: To compare the performance of three reference tissue models (RTMs) and
parameter estimation algorithms for quantification of [11 C] Pittsburgh compound B ([11 C] …

401 Objectives Ultrafiltration is the most common method of determining plasma free fraction
(f P) for brain PET radioligands (ratio of free concentration to free plus protein-bound …

PET provides a uniquely sensitive and powerful means for studying a clinically relevant
protein target within the brain, provided that an adequately specific and sensitive radiotracer …

Introduction The adenosine triphosphate-binding cassette (ABC) transporter P-glycoprotein
(Pgp) protects the brain from accumulation of lipophilic compounds by active efflux transport …

The incidence of neurological diseases increases perpetually, on the one hand, due to the
rising incidence of psychiatric diseases in young people and on the other hand due to an …

335 Objectives: To evaluate three reference tissue models (RTMs) as compared to the
compartmental model with plasma input for quantification of ligand-receptor dynamic PET …

The aim of this study was to assess the reliability of 2′-methoxyphenyl-(N-2′-pyridinyl)-p-
18F-fluoro-benzamidoethylpiperazine (18F-MPPF) PET binding parameter's quantification …