MATERIALS AND METHODS Lym-1 (Techniclone, Inc., Tustin, CA) is a murine IgGla MAb
specific for membrane antigens found on malignant cells of most patients with B-cell …

A newly developed murine monoclonal antibody, designated Lym-1, has been produced by
the fusion of Raji Burkitt's lymphoma-primed splenocytes and NS-1 mouse myeloma cells …

Eighteen patients with Stage 4 B-cell malignancies, which were primarily of intermediate or
high grade and progressive despite multiple drug chemotherapy and external irradiation …

Copper-67 (Ā7Cu) is one of the most promising radiometals for radioimmunotherapy
because of its 61.5 hr physicalhalf-life, abundantbeta particles …

Lym‐1 is a murine IgG2a monoclonal antibody (MAb) that is B‐cell specific but has greater
avidity for malignant B cells when compared with normal B lymphocytes. It was originally …

Severalmonoclonalantibodies, includingLym-1, haveproveneffec tive for treatment of
hematologic malignancies. Lym-1, which prefer en@ targets malignant lymphocytes, has …

Sixteen patients with non-Hodgkin's lymphoma were infused with 6.2 to 58.2 mCi (0.2 to 3.9
mg) doses of radioactive iodine (131I)-labeled LL2 immunoglobulin G (IgG) or F (ab') 2, in …

The malignant cells should also be highly radiosensitive. B-Lymphocyte malignancies, such
as non-Hodgkin's lymphomas and chronic lymphocytic leukemias, seemed to satisfy these …

Thirteen patients with relapsed or refractory Non-Hodgkin's Lymphoma were treated with
131I-Lym-1 during the course of a dose escalation trial. Principal aims were to establish the …

Antilymphoma mouse monoclonal antibody (MoAb) Lym-1, labeled with 67Cu or 131I, has
demonstrated promising results in radioimmunotherapy (RIT) for lymphoma. Although 131I …