Impact of reference and target region selection on amyloid PET SUV ratios in the phase 1b PRIME study of aducanumab
P Chiao, BJ Bedell, B Avants… - Journal of Nuclear …, 2019 - Soc Nuclear Med
SUV ratios (SUVRs) are commonly used to quantify tracer uptake in amyloid-β PET. Here,
we explore the impact of target and reference region-of-interest (ROI) selection on SUVR …
we explore the impact of target and reference region-of-interest (ROI) selection on SUVR …
Amyloid load: a more sensitive biomarker for amyloid imaging
A Whittington, RN Gunn - Journal of Nuclear Medicine, 2019 - Soc Nuclear Med
Amyloid-β (Aβ) plays a key role in the pathogenesis of Alzheimer disease (AD) and can be
imaged in vivo using 18F-florbetapir PET. A composite SUV ratio (SUVr) is a commonly used …
imaged in vivo using 18F-florbetapir PET. A composite SUV ratio (SUVr) is a commonly used …
Optimal reference region to measure longitudinal amyloid-β change with 18F-Florbetaben PET
S Bullich, VL Villemagne, AM Catafau… - Journal of Nuclear …, 2017 - Soc Nuclear Med
Accurate measurement of changes in amyloid-β (Aβ) deposition over time is important in
longitudinal studies, particularly in anti-Aβ therapeutic trials. To achieve this, the optimal …
longitudinal studies, particularly in anti-Aβ therapeutic trials. To achieve this, the optimal …
Performance characteristics of amyloid PET with florbetapir F 18 in patients with Alzheimer's disease and cognitively normal subjects
AD Joshi, MJ Pontecorvo, CM Clark… - Journal of Nuclear …, 2012 - Soc Nuclear Med
The objectives of this study were to examine the effective dose range and the test–retest
reliability of florbetapir F 18 using, first, visual assessment by independent raters masked to …
reliability of florbetapir F 18 using, first, visual assessment by independent raters masked to …
[HTML][HTML] Using PET with 18F-AV-45 (florbetapir) to quantify brain amyloid load in a clinical environment
Purpose Positron emission tomography (PET) imaging of brain amyloid load has been
suggested as a core biomarker for Alzheimer's disease (AD). The aim of this study was to …
suggested as a core biomarker for Alzheimer's disease (AD). The aim of this study was to …
Improved power for characterizing longitudinal amyloid-β PET changes and evaluating amyloid-modifying treatments with a cerebral white matter reference region
K Chen, A Roontiva, P Thiyyagura, W Lee… - Journal of Nuclear …, 2015 - Soc Nuclear Med
In this article, we describe an image analysis strategy with improved power for tracking
longitudinal amyloid-β (Aβ) PET changes and evaluating Aβ-modifying treatments. Methods …
longitudinal amyloid-β (Aβ) PET changes and evaluating Aβ-modifying treatments. Methods …
Reference region selection and the association between the rate of amyloid accumulation over time and the baseline amyloid burden
J Blautzik, M Brendel, J Sauerbeck, S Kotz… - European journal of …, 2017 - Springer
Relative quantitative analysis of amyloid plaque burden in Alzheimer's disease (AD) patients
can be reported as standardized uptake value ratio (SUVR) from positron emission …
can be reported as standardized uptake value ratio (SUVR) from positron emission …
[HTML][HTML] Reference tissue normalization in longitudinal 18F-florbetapir positron emission tomography of late mild cognitive impairment
Background Semiquantitative methods such as the standardized uptake value ratio (SUVR)
require normalization of the radiotracer activity to a reference tissue to monitor changes in …
require normalization of the radiotracer activity to a reference tissue to monitor changes in …
Validation of noninvasive tracer kinetic analysis of 18F-florbetaben PET using a dual–time-window acquisition protocol
S Bullich, H Barthel, N Koglin, GA Becker… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Accurate amyloid PET quantification is necessary for monitoring amyloid-β accumulation
and response to therapy. Currently, most of the studies are analyzed using the static SUV …
and response to therapy. Currently, most of the studies are analyzed using the static SUV …
Longitudinal head-to-head comparison of 11C-PiB and 18F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-β monoclonal antibodies in dominantly …
Abstract Purpose Pittsburgh Compound-B (11C-PiB) and 18F-florbetapir are amyloid-β (Aβ)
positron emission tomography (PET) radiotracers that have been used as endpoints in …
positron emission tomography (PET) radiotracers that have been used as endpoints in …