Cardiac toxicity of cocaine has been linked to its inhibitory effect on norepinephrine reuptake
by sympathetic nerve terminals of the heart. Carbon-11-hydroxyephedrine is a positron …

Objectives. The aim of the study was to define the effect of cocaine on the myocardial uptake
and retention of C-11 hydroxyephedrine in the anesthetized dog model. Background …

Abstract Positron emission tomography (PET),[11C] cocaine, and (–)‐6‐[18F]
fluoronorepinephrine [(‐)‐6‐[18F] NE] were used to determine the extent to which the …

The toxic properties of cocaine are related to both the central and peripheral effects. To
identify possible lethal mechanisms and the accumulation of cocaine in various organs, the …

The frequent use of cocaine in the United States has resulted in a high degree of morbidity
and mortality. Although cocaine was initially believed to be a relatively safe drug, there is …

Many of the cardiovascular effects of cocaine have been attributed to sympathomimetic
actions of the drug. The peripheral nervous system and the brain have been studied as …

The sympathomimetic drug phenylephrine recently has been la beled with 11C for use in
PET studies of cardiac sympathetic innervation. Previous reports using isolated perfused rat …

Cocaine cardiotoxicity is partly due to sympathetic activation of the heart resulting from
inhibition of catecholamine uptake at the sympathetic nerve terminal and possible central …

We have compared the effects of methylenedioxymethamphetamine (MDMA),
methylenedioxyethylamphetamine (MDEA), methylenedioxyamphetamine (MDA) and …

The norepinephrine analog 11C-meta-hydroxyephedrine (HED) is used with PET to map the
regional distribution of cardiac sympathetic neurons. HED is rapidly transported into …