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Optimized peptide amount and activity for 90Y-labeled DOTATATE therapy

P Kletting, T Kull, C Maaß, N Malik… - Journal of Nuclear …, 2016 - Soc Nuclear Med
In peptide receptor radionuclide therapy with 90Y-labeled DOTATATE, the kidney absorbed
dose limits the maximum amount of total activity that can be safely administered in many …
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[PDF] researchgate.net

Results of Individual Patient Dosimetry in Peptide Receptor Radionuclide Therapy with 177Lu DOTA-TATE and 177Lu DOTA-NOC

C Wehrmann, S Senftleben, C Zachert… - Cancer biotherapy & …, 2007 - liebertpub.com
One of the few treatment options for inoperable neuroendocrine tumors (NET) is peptide
receptor radiotherapy with somatostatin analogs. In this study, we compared the dosimetric …
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[PDF] academia.edu

Differences in predicted and actually absorbed doses in peptide receptor radionuclide therapy

P Kletting, B Müller, B Erentok, J Schmaljohann… - Medical …, 2012 - Wiley Online Library
Purpose: An important assumption in dosimetry prior to radionuclide therapy is the
equivalence of pretherapeutic and therapeutic biodistribution. In this study the authors …
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90Y-DOTATOC dosimetry–based personalized peptide receptor radionuclide therapy

Y Menda, MT Madsen, TM O'Dorisio… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Pretherapy PET with 86Y-DOTATOC is considered the ideal dosimetry protocol for 90Y-
DOTATOC therapy; however, its cost, limited availability, and need for infusion of amino …
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The Bad Berka Dose Protocol: Comparative Results of Dosimetry in Peptide Receptor Radionuclide Therapy Using 177Lu-DOTATATE, 177Lu-DOTANOC, and 177 …

C Schuchardt, HR Kulkarni, V Prasad, C Zachert… - … , Gallium-68, and Other …, 2013 - Springer
Purpose: The objective of this study is to analyze the in vivo behavior of the 177 Lu-labeled
peptides DOTATATE, DOTANOC, and DOTATOC used for peptide receptor radionuclide …
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[PDF] researchgate.net

The Influence of Early Measurements Onto the Estimated Kidney Dose in [177Lu][DOTA0,Tyr3]Octreotate Peptide Receptor Radiotherapy of Neuroendocrine …

A Delker, H Ilhan, C Zach, J Brosch… - Molecular imaging and …, 2015 - Springer
Purpose Multiple measurements have been required to estimate the radiation dose to the
kidneys resulting from [177 Lu] DOTATATE therapy for neuroendocrine tumors. The aim of …
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[PDF] academia.edu

On the preparation of a therapeutic dose of 177Lu-labeled DOTA–TATE using indigenously produced 177Lu in medium flux reactor

T Das, S Chakraborty, S Banerjee… - Applied radiation and …, 2007 - Elsevier
177Lu could be produced with a specific activity of∼ 23,000 mCi/mg (850GBq/mg) by
neutron activation using enriched 176Lu (64.3%) target when irradiation was carried out at a …
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[HTML] springer.com

[HTML][HTML] Renal function affects absorbed dose to the kidneys and haematological toxicity during 177Lu-DOTATATE treatment

J Svensson, G Berg, B Wängberg, M Larsson… - European journal of …, 2015 - Springer
Purpose Peptide receptor radionuclide therapy (PRRT) has become an important treatment
option in the management of advanced neuroendocrine tumours. Long-lasting responses …
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[HTML][HTML] Kidney dosimetry in 777 patients during 177Lu-DOTATATE therapy: aspects on extrapolations and measurement time points

M Sandström, N Freedman, K Fröss-Baron, T Kahn… - EJNMMI physics, 2020 - Springer
Purpose Fractionated peptide receptor radionuclide therapy (PRRT) with 177 Lu-
DOTATATE is increasingly applied as an effective treatment for patients with disseminated …
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[HTML] plos.org

[HTML][HTML] Software-assisted dosimetry in peptide receptor radionuclide therapy with 177Lutetium-DOTATATE for various imaging scenarios

D Kupitz, C Wetz, H Wissel, F Wedel, I Apostolova… - PloS one, 2017 - journals.plos.org
In peptide receptor radionuclide therapy (PRRT) of patients with neuroendocrine neoplasias
(NENs), intratherapeutic dosimetry is mandatory for organs at risk (eg kidneys) and tumours …
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