The imaging research of chemokine receptor 4
P Xu - 2018 - Soc Nuclear Med
1794 Objectives: To investigate the possibility of using CXCR4 siRNA labeled with 99m Tc
for the breast cancer CXCR4 gene imaging in nude mice. Methods:(1) The siRNAs targeting …
for the breast cancer CXCR4 gene imaging in nude mice. Methods:(1) The siRNAs targeting …
Synthesis and evaluation of a 99mTc-labeled chemokine receptor antagonist peptide for imaging of chemokine receptor expressing tumors
A Mikaeili, M Erfani, O Sabzevari - Nuclear Medicine and Biology, 2017 - Elsevier
Objective The chemokine receptor CXCR4 is highly expressed in tumor cells and plays an
important role in tumor metastasis. In the present study, we report on the evaluation of a new …
important role in tumor metastasis. In the present study, we report on the evaluation of a new …
99mTc–AMD3100: A novel potential receptor-targeting radiopharmaceutical for tumor imaging
JM Zhang, JH Tian, TR Li, HY Guo, L Shen - Chinese Chemical Letters, 2010 - Elsevier
The chemokine CXCR4 receptor is over-expressed in a wide variety of tumors. In this study,
AMD3100, which was a prototype non-peptide antagonist of CXCR4 receptor, was labeled …
AMD3100, which was a prototype non-peptide antagonist of CXCR4 receptor, was labeled …
Imaging CXCR4 Expression with 99mTc-Radiolabeled Small-Interference RNA in Experimental Human Breast Cancer Xenografts
P Fu, L Tian, X Cao, L Li, P Xu, C Zhao - Molecular imaging and biology, 2016 - Springer
Purpose Noninvasive quantification of chemokine receptor 4 (CXCR4) expression could
serve as a prognostic indicator and may be of value for the design of personalized therapies …
serve as a prognostic indicator and may be of value for the design of personalized therapies …
Development of a novel 99mTc‐labeled small molecular antagonist for CXCR4 positive tumor imaging
X Zhang, L You, S Chen, M Gao, Z Guo… - Journal of Labelled …, 2018 - Wiley Online Library
The chemokine receptor 4 (CXCR4) has been an attractive molecular target for tumor
imaging, because it is overexpressed in many tumor types and involved in tumor …
imaging, because it is overexpressed in many tumor types and involved in tumor …
Imaging CXCR4 expression in breast cancer metastasis models using [64Cu] AMD3465
M Pullambhatla, L Woodard, R De Silva, K Peyre… - 2012 - Soc Nuclear Med
519 Objectives The chemokine receptor 4 (CXCR4) is highly expressed in breast cancer
and is critical for metastasis. To evaluate the potential of CXCR4-based imaging agents to …
and is critical for metastasis. To evaluate the potential of CXCR4-based imaging agents to …
Synthesis & biological evaluation of 99mTc-AMD3465 as a SPECT tracer for CXCR4 receptor imaging.
J Zhang, X Zhang, J Tian - 2018 - Soc Nuclear Med
1119 Objectives: Purpose A number of attempts have been made to non-invasively image
CXCR4 receptor, such as 64 Cu-AMD3100 & 68 Ga-Pentixafor. AMD3465 was successfully …
CXCR4 receptor, such as 64 Cu-AMD3100 & 68 Ga-Pentixafor. AMD3465 was successfully …
Development of peptide based CXCR4 chemokine receptor imaging agents
L Tarallo, S De Luca, R Della Moglie, A D'Alessio… - 2006 - Soc Nuclear Med
1861 Objectives: CXCR4 is a G-protein-coupled chemokine receptor that is overexpressed
in a variety of cancers including breast and melanoma. It represents an interesting target for …
in a variety of cancers including breast and melanoma. It represents an interesting target for …
Research progress of CXC chemokine receptor type 4 and molecular imaging in tumors
L Li, C Zhao, G Tian - International Journal of Radiation Medicine and …, 2014 - inis.iaea.org
[en] CXC chemokine receptor type 4 (CXCR4) and its ligand (CXCL12) exerts crucial
influence in regulating tumor growth, angiogenesis and metastasis. Studies show that the …
influence in regulating tumor growth, angiogenesis and metastasis. Studies show that the …
Construction of a siRNA Expression Plasmid Targeting CXCR4 and Its Effect on the invasion ability of the breast cancer cell
J FENG, J Dong, M Hong… - Basic & Clinical …, 2009 - journal11.magtechjournal.com
Objective To construct and identify the siRNA eukaryotic expression vector targeting gene
CXC chemokine receptor-4 and study its role in invasion ability of bread cancer cells …
CXC chemokine receptor-4 and study its role in invasion ability of bread cancer cells …