Non–catechol-based high-affinity selective dopamine D1 receptor (D1R) agonists were
recently described, and candidate PET ligands were selected on the basis of favorable …

360 Objectives Dopamine D 2 and D 3 (D 2/D 3) receptors agonist PET radioligands have
recently been demonstrated to have improved sensitivity to endogenous dopamine level …

159 Objectives PET tracers for dopamine D 2-like receptors display little selectivity for D 2
and D 3 receptors. Consequently, the differential distribution of D 2 and D 3 receptors in …

PET has been used to examine changes in neurotransmitter concentrations in the living
brain. Pioneering PET studies on the dopamine system have used D2 and D3 receptor …

1108 Objectives D 2/3-agonist PET tracers are more sensitive to endogenous dopamine
levels than D 2/3-antagonists [1] and offer, at least in theory, the opportunity to study the high …

1815 Objectives: 11C-NNC 112 is useful for PET measurement of D1-like dopamine
receptor binding in vivo. We have determined the absorbed radiation dosimetry of iv …

NNC 22-0010 is a new dopamine antagonist with a high affinity and selectivity for D1
receptors in vitro. NNC 22-0010 has both an N-methyl group and a bromine, which allows …

565 Objectives: Partial agonists or antagonists of D 3 ligands that can reduce the interaction
of psychostimulant-induced increases in synaptic dopamine levels with the D 3 receptor may …

Introduction The dopamine D 4 receptor (D 4 R) has attracted considerable attention as
potential target for the treatment of a broad range of central nervous system disorders …

859 Objectives: Dysfunction of the dopaminergic system has been implicated in neurological
and psychiatric disorders such as Parkinson's disease, schizophrenia, depression and …