Adenosine 2A receptor occupancy by tozadenant and preladenant in rhesus monkeys
O Barret, J Hannestad, D Alagille, C Vala… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Motor symptoms in Parkinson disease (PD) are caused by a loss of dopamine input from the
substantia nigra to the striatum. Blockade of adenosine 2A (A2A) receptors facilitates …
substantia nigra to the striatum. Blockade of adenosine 2A (A2A) receptors facilitates …
Initial evaluation of an adenosine A2A receptor ligand, 11C-preladenant, in healthy human subjects
M Sakata, K Ishibashi, M Imai… - Journal of Nuclear …, 2017 - Soc Nuclear Med
11C-preladenant is a selective antagonist for mapping of cerebral adenosine A2A receptors
(A2ARs) by PET. This is a first-in-human study to examine the safety, radiation dosimetry …
(A2ARs) by PET. This is a first-in-human study to examine the safety, radiation dosimetry …
Characterization in humans of 18F-MNI-444, a PET radiotracer for brain adenosine 2A receptors
O Barret, J Hannestad, C Vala, D Alagille… - Journal of Nuclear …, 2015 - Soc Nuclear Med
PET with selective adenosine 2A receptor (A2A) radiotracers can be used to study a variety
of neurodegenerative and neuropsychiatric disorders in vivo and to support drug-discovery …
of neurodegenerative and neuropsychiatric disorders in vivo and to support drug-discovery …
In vivo evaluation of 11C-preladenant for PET imaging of adenosine A2A receptors in the conscious monkey
X Zhou, R Boellaard, K Ishiwata, M Sakata… - Journal of Nuclear …, 2017 - Soc Nuclear Med
11C-preladenant was developed as a novel PET ligand for the adenosine A2A receptors
(A2ARs). The present study aimed to evaluate the suitability of 11C-preladenant PET for the …
(A2ARs). The present study aimed to evaluate the suitability of 11C-preladenant PET for the …
In vivo evaluation of [(123) I] MNI-420: a novel single photon emission computed tomography radiotracer for imaging of adenosine 2A receptors in brain.
AA Tavares, J Batis, O Barret, D Alagille… - Nuclear Medicine and …, 2013 - europepmc.org
Methods Two adult male monkeys (Macaca fascicularis) and three adult female baboons
(Papio anubis) were anesthetized and imaged on Neurofocus SPECT cameras. Baboons …
(Papio anubis) were anesthetized and imaged on Neurofocus SPECT cameras. Baboons …
In vivo evaluation of [11C]preladenant positron emission tomography for quantification of adenosine A2A receptors in the rat brain
X Zhou, S Khanapur, JR de Jong… - Journal of Cerebral …, 2017 - journals.sagepub.com
[11C] Preladenant was developed as a novel adenosine A2A receptor positron emission
tomography radioligand. The present study aims to evaluate the suitability of [11C] …
tomography radioligand. The present study aims to evaluate the suitability of [11C] …
Use of 11C-MPDX and PET to study adenosine A1 receptor occupancy by nonradioactive agonists and antagonists
S Paul, S Khanapur, JW Sijbesma… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Adenosine A1 receptors (A1Rs) in human and rodent brains can be visualized with the
radioligand 8-dicyclopropylmethyl-1-11C-methyl-3-propylxanthine (11C-MPDX) and PET …
radioligand 8-dicyclopropylmethyl-1-11C-methyl-3-propylxanthine (11C-MPDX) and PET …
Small-animal PET study of adenosine A1 receptors in rat brain: blocking receptors and raising extracellular adenosine
S Paul, S Khanapur, AA Rybczynska… - Journal of Nuclear …, 2011 - Soc Nuclear Med
Activation of adenosine A1 receptors (A1R) in the brain causes sedation, reduces anxiety,
inhibits seizures, and promotes neuroprotection. Cerebral A1R can be visualized using 8 …
inhibits seizures, and promotes neuroprotection. Cerebral A1R can be visualized using 8 …
Mapping adenosine A1 receptors in the cat brain by positron emission tomography with [11C] MPDX
Y Shimada, K Ishiwata, M Kiyosawa, T Nariai… - Nuclear medicine and …, 2002 - Elsevier
We evaluated the potential of [11C] MPDX as a radioligand for mapping adenosine A1
receptors in comparison with previously proposed [11C] KF15372 in cat brain by PET. Two …
receptors in comparison with previously proposed [11C] KF15372 in cat brain by PET. Two …
Synthesis and evaluation of [11C] FR194921 as a nonxanthine-type PET tracer for adenosine A1 receptors in the brain
T Matsuya, H Takamatsu, Y Murakami, A Noda… - Nuclear medicine and …, 2005 - Elsevier
This report describes the synthesis of [11C] 2-(1-methyl-4-piperidinyl)-6-(2-phenylpyrazolo
[1, 5-a] pyridin-3-yl)-3 (2H)-pyridazinone ([11C] FR194921), a highly selective, nonxanthine …
[1, 5-a] pyridin-3-yl)-3 (2H)-pyridazinone ([11C] FR194921), a highly selective, nonxanthine …