The probability of atherosclerotic plaque rupture and its thrombotic sequelae are thought to
be increased at sites of macrophage accumulation. Folate receptor β (FR-β) is present on …

In atherosclerotic plaques, the risk of rupture is increased at sites of macrophage
accumulation. Activated macrophages express folate receptor-β (FR-β), which can be …

Folate receptor β (FR-β) is overexpressed on activated, but not resting, macrophages
involved in a variety of inflammatory and autoimmune diseases. A pivotal step in …

The need for noninvasive imaging to distinguish stable from vulnerable atherosclerotic
plaques is evident. Activated macrophages play a role in atherosclerosis and express folate …

Inflammation plays an important role in the development of atherosclerosis and its
complications. Because the folate receptor β (FR-β) is selectively expressed on …

Introduction: Macrophages are a major cell type in inflamed atherosclerotic plaques. Since
folate receptor β (FR-β) is highly expressed in activated macrophages, we hypothesized that …

Background—18F-fluorocholine (18F-FCH) uptake is associated with cell proliferation and
activity in tumor patients. We hypothesized that 18F-FCH could similarly be a valuable …

The objective of this study is to compare a series of albumin-based folate radiotracers for the
potential imaging of folate receptor (FR) positive macrophages in advanced atherosclerotic …

To investigate the association between gene expression of key molecular markers of
hypoxia and inflammation in atherosclerotic carotid lesions with 2-deoxy-2-[18 F] fluoro-D …

Folate receptor β (FR-β), a marker expressed on macrophages, is a promising target for
imaging of inflammation. Here, we report the radiosynthesis and preclinical evaluation of …