[PDF][PDF] Intratumoral distribution of radiolabeled antibody and radioimmunotherapy in experimental liver metastases model of nude mouse

N Sato, T Saga, H Sakahara, Z Yao… - Journal of Nuclear …, 1999 - Soc Nuclear Med
ConclusIon: Liver metastaseshad easy accessibilityto the antibody. Micrometastasesof less
than 0.5 mm in diameter showed homogeneousintratumoraldistribution of injected anti body …

Radioimmunotherapy for liver micrometastases in mice: pharmacokinetics, dose estimation, and long‐term effect

T Saga, H Sakahara, Y Nakamoto… - Japanese journal of …, 1999 - Wiley Online Library
The pharmacokinetics of a therapeutic dose of 131I‐labeled antibody and the absorbed
dose in liver micrometastases of human colon cancer LS174T in female BALB/c nu/nu mice …

Radioimmunotherapy with 186Re-Labeled Monoclonal Antibody to Treat Liver Metastases of Colon Cancer Cells in Nude Mice

S Kinuya, K Yokoyama, A Kawashima… - Cancer Biotherapy …, 2002 - liebertpub.com
The efficacy of radioimmunotherapy (RIT) in the treatment of minimal disease has been
previously shown, despite the limitation of β-emitters suggested by a mathematical model. In …

The mechanism of hepatic uptake of a radiolabelled monoclonal antibody

CC Boyle, AJ Paine, SJ Mather - International journal of cancer, 1992 - Wiley Online Library
Clinical and experimental scintigraphic studies have found that radiolabelled antibodies are
not only taken up by tumour (s) but also by normal liver. The accumulation of radio nuclides …

[PDF][PDF] Biokinetics of radiolabeled monoclonal antibodies in heterotransplanted nude rats: evaluation of corrected specific tissue uptake

C Ingvar, K Norrgren, SE Strand, T Brodin… - Journal of nuclear …, 1989 - Soc Nuclear Med
A tumormodelis presented to study the biokineticsand localizationof radiolabeled
monoclonalantibodies (MAb) in the nude rat (Rowett RNu/RNu) heterotranspianted with …

[PDF][PDF] A general, extracorporeal immunoadsorption method to increase the tumor-to-normal tissue ratio in radioimmunoimaging and radioimmunotherapy

K Norrgren, SE Strand, R Nilsson… - Journal of Nuclear …, 1993 - Soc Nuclear Med
Timeafter injectionInjected antibodyECIA treatmentNumber of rats24 hr1-96.5 no424 hr1-
96.5-blotinno524 hr1-96.5-biotinyes648 hr1-96.5 no448 hr1-96.5-biotinno448 hr1-96.5 …

Biodistribution and therapeutic efficacy of 125/131I-, 186Re-, 88/90Y-, or 177Lu-labeled monoclonal antibody MN-14 to carcinoembryonic antigen in mice with small …

MJ Koppe, RP Bleichrodt, AC Soede… - Journal of nuclear …, 2004 - Soc Nuclear Med
Therapeutic efficacy in radioimmunotherapy depends, among other things, on the choice of
the radionuclide. The aim of the present study was to determine the most suitable …

Tumor Retention of 186Re-MAG3, 111In-DTPA and 125I Labeled Monoclonal Antibody G250 in Nude Mice with Renal Cell Carcinoma Xenografts

MG Steffens, M Kranenborg, OC Boerman… - Cancer biotherapy & …, 1998 - liebertpub.com
In radioimmunotherapy of solid tumors substantial gain might be achieved by carefully
selecting the radionuclide and the linker connecting it to the antibody. In contrast to 131I …

Radioimmunotherapy and fractionated radiotherapy of human colon cancer liver metastases in nude mice

CA Vogel, MC Galmiche, F Buchegger - Cancer research, 1997 - AACR
Radioimmunotherapy (RIT) and radiotherapy (RT) were evaluated in nude mice developing
liver metastases of human colon cancer. Without treatment, 90% of preconditioned nude …

[PDF][PDF] Enhancement of tumor-to-nontumor localization ratios by hepatocyte-directed blood clearance of antibodies labeled with certain residualizing radiolabels

S Patel, R Stein, GL Ong, DM Goldenberg… - Journal of Nuclear …, 1999 - Soc Nuclear Med
The cell lines and their growth conditions were previously described (4, 11). Calu-3 lung
carcinoma cells were propagated in vitro, and lO@ tissue culture cells were injected …