Treatment monitoring of immunotherapy and targeted therapy using 18F-FET PET in patients with melanoma and lung cancer brain metastases: initial experiences

N Galldiks, DSY Abdulla, M Scheffler… - Journal of nuclear …, 2021 - Soc Nuclear Med
We investigated the value of O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) PET for treatment
monitoring of immune checkpoint inhibition (ICI) or targeted therapy (TT) alone or in …

18F-FET PET for diagnosis of pseudoprogression of brain metastases in patients with non–small cell lung cancer

D Akhoundova, S Hiltbrunner, C Mader… - Clinical nuclear …, 2020 - journals.lww.com
Purpose To evaluate whether 18 F-fluoroethyltyrosine (FET) PET can discriminate
progression from pseudoprogression of brain metastases in patients with non–small cell …

[HTML][HTML] Targeted therapy and immunotherapy response assessment with F-18 fluorothymidine positron-emission tomography/magnetic resonance imaging in …

NC Nguyen, MK Yee, AM Tuchayi, JM Kirkwood… - Frontiers in …, 2018 - frontiersin.org
Introduction This pilot study aimed at exploring the utility of the proliferation tracer F-18
fluorothymidine (FLT) and positron-emission tomography (PET)/magnetic resonance …

18F-FET PET uptake characteristics in patients with newly diagnosed and untreated brain metastasis

M Unterrainer, N Galldiks, B Suchorska… - Journal of nuclear …, 2017 - Soc Nuclear Med
In patients with brain metastasis, PET using labeled amino acids has gained clinical
importance, mainly regarding the differentiation of viable tumor tissue from treatment-related …

[HTML][HTML] Suspected recurrence of brain metastases after focused high dose radiotherapy: can [18F]FET- PET overcome diagnostic uncertainties?

A Romagna, M Unterrainer, C Schmid-Tannwald… - Radiation …, 2016 - Springer
Background After focused high dose radiotherapy of brain metastases, differentiation
between tumor recurrence and radiation-induced lesions by conventional MRI is …

18F-BMS986192 PET imaging of PD-L1 in metastatic melanoma patients with brain metastases treated with immune checkpoint inhibitors: a pilot study

PH Nienhuis, IF Antunes… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein-1 (PD-
1)/programmed cell death ligand-1 (PD-L1) frequently induces tumor response in metastatic …

Hybrid 18F-fluoroethyltyrosine PET and MRI with perfusion to distinguish disease progression from treatment-related change in malignant brain tumors: the quest to …

NJ Smith, TK Deaton, W Territo, B Graner… - Journal of Nuclear …, 2023 - Soc Nuclear Med
Conventional MRI has important limitations when assessing for progression of disease
(POD) versus treatment-related changes (TRC) in patients with malignant brain tumors. We …

Imaging challenges of immunotherapy and targeted therapy in patients with brain metastases: response, progression, and pseudoprogression

N Galldiks, M Kocher, G Ceccon, JM Werner… - Neuro …, 2020 - academic.oup.com
The advent of immunotherapy using immune checkpoint inhibitors (ICIs) and targeted
therapy (TT) has dramatically improved the prognosis of various cancer types. However …

O-(2-18F-fluoroethyl)-L-tyrosine PET for evaluation of brain metastasis recurrence after radiotherapy: an effectiveness and cost-effectiveness analysis

A Heinzel, D Müller, SS Yekta-Michael… - Neuro …, 2017 - academic.oup.com
Background Conventional MRI is the standard method to diagnose recurrence of brain
metastases after radiation. However, following radiation therapy, reactive transient blood …

Role of O-(2-18F-fluoroethyl)-L-tyrosine PET for differentiation of local recurrent brain metastasis from radiation necrosis

N Galldiks, G Stoffels, CP Filss, MD Piroth… - Journal of Nuclear …, 2012 - Soc Nuclear Med
The aim of this study was to investigate the potential of O-(2-18F-fluoroethyl)-l-tyrosine (18F-
FET) PET for differentiating local recurrent brain metastasis from radiation necrosis after …