Tumor hypoxia in head-and-neck squamous cell carcinoma (HNSCC) leads to an
immunosuppressive microenvironment and reduces the response to radiotherapy. In this …

Tumor-associated hypoxia influences the radiation response of head-and-neck cancer
(HNSCC) patients, and a lack of early hypoxia resolution during treatment considerably …

Purpose Tumor hypoxia impairs the response of head-and-neck cancer (HNSCC) patients to
radiotherapy and can be detected both by tissue biomarkers and PET imaging. However, the …

Purpose Intratumoral hypoxia increases resistance of head-and-neck squamous cell
carcinoma (HNSCC) to radiotherapy.[18 F] FMISO PET imaging enables noninvasive …

Results High HIF1α H-scores in the tumor were found to significantly correlate with
increased tumor hypoxia during the first weeks of treatment as assessed by the difference in …

Purpose As both tumor hypoxia and an immunosuppressing tumor microenvironment
hamper the anti-tumor activity of radiotherapy in head-and-neck squamous cell carcinoma …

Background Hypoxia is a well recognised parameter of tumour resistance to radiotherapy, a
number of anticancer drugs and potentially immunotherapy. In a previously published …

Background Radiotherapy plays an important role in the treatment of pharyngo-laryngeal
and oral cavity head and neck squamous cell carcinoma (HNSCC) either as single modality …

Background Tumor hypoxia worsens the prognosis of head-and-neck squamous cell
carcinoma (HNSCC) patients, and plasma hypoxia markers may be used as biomarkers for …

Background and purpose Increased tumour hypoxia is associated with a worse overall
survival in patients with head and neck squamous cell carcinoma (HNSCC). The aims of this …