1749 Objectives There are two major sources of cholinergic projections in the brain. The
nucleus basalis of Meynert provides the principal cholinergic input of the cortical mantle and …

557 Objectives There are two major sources of cholinergic projections in the brain. The
nucleus basalis of Meynert provides the principal cholinergic input of the cortical mantle and …

470 Objectives To examine levels of neocortical and thalamic acetylcholinesterase (AChE)
activity in Parkinson disease (PD) subjects relative to normal values in non-PD elderly …

Evidence for cholinergic dysfunction in very early stages of neurodegeneration like mild
cognitive impairment (MCI) is inconclusive. Previous positron emission tomography (PET) …

1258 Objectives [11C] N-methyl-4-piperidyl acetate (MP4A) is a positron emission
tomography (PET) tracer for cerebral acetylcholine esterase (AChE) activity as a marker of …

Background Dysfunction of the cholinergic system is well-known in Alzheimer's disease
(AD), but specific alterations in cholinergic neurotransmission, their regional distribution, and …

1276 Objectives Glucose metabolic studies have shown reduced activity in the primary
occipital cortex (Brodmann area, BA, 17) in Parkinson disease without dementia …

Background The deterioration of the central cholinergic system in aging is hypothesized to
underlie declines in several cognitive domains, including memory and executive functions …

In a series of translational experiments using fully quantitative positron emission tomography
(PET) imaging with a new tracer specific for the vesicular acetylcholine transporter ([18 F] …

There are two major sources of cholinergic projections in the brain. The nucleus basalis of
Meynert provides the principal cholinergic input of the cortical mantle and the …