Metastatic disease to bone is commonly seen in the advanced stages of many cancers. The
cardinal symptom, pain, is often the cause of significant morbidity and reduced quality of life …

The element radium (Ra) was discovered by the Curies in 1898 and within a decade was in
broad scientific testing for the management of several forms of cancer. The compound was …

Bone metastasis occurs as a result of a complex pathophysiologic process between host
and tumor cells leading to cellular invasion, migration adhesion, and stimulation of …

Many patients with cancer develop symptomatic skeletal metastases at an advanced stage
of their disease. Skeletal metastases are often complicated by pain. They cause …

Bone is a common metastatic site of cancer. Bone metastasis reduces life expectancy and
results in serious symptoms and complications such as bone pain, pathological fractures …

Background Pain from skeletal metastases represents a major burden of advanced disease
from solid tumors. Analgesic medications, bisphosphonates, hormonal agents, cytotoxic …

Skeletal metastases occur in many patients with different kinds of malignant tumors,
especially in advance stage of breast cancer (in 47%–85% of patients), prostate cancer (33 …

The skeleton is the most common metastatic site in patients with advanced cancer. Pain is a
major healthcare problem in patients with bone metastases. Bone-seeking radionuclides …

Pain palliation with bone-seeking radiopharmaceuticals is an effective and cost-effective
management tool in patients with advanced cancer metastatic to bone. Strontium-89 …

Bone pain due to skeletal metastases constitutes the most common type of chronic pain
among patients with cancer. It significantly decreases the patient's quality of life and is …