Radiation dose estimations are key for optimizing therapies. We studied the role of 124I-
omburtamab (8H9) given intraventricularly in assessing the distribution and radiation doses …

Purpose Radioimmunotherapy (RIT) delivered through the cerebrospinal fluid (CSF) has
been shown to be a safe and promising treatment for leptomeningeal metastases …

Background The prognosis for metastatic and recurrent tumors of the central nervous system
(CNS) remains dismal, and the need for newer therapeutic targets and modalities is critical …

Abstract Radioimmunotherapy (RIT) with 131I-labeled L19SIP (radretumab; a small
immunoprotein format antibody directed against the ED-B domain of fibronectin;∼ 80 kDa …

Leptomeningeal dissemination of a primary brain tumor is a condition which is challenging
to treat, as it often occurs in rather late disease stages in highly pretreated patients. Its …

Leptomeningeal metastasis (LM), ie the seeding of tumor cells to the cerebrospinal fluid
(CSF) and the leptomeninges, is a devastating and mostly late-stage complication of various …

Results To date, 61 pts (M/F, 22/39; median age 57 y) have been treated. Baseline KPS was
70, 80, 90, and 100 in 8.2, 31.1, 39.3, and 21.3% pts, respectively; primary tumor types were …

Purpose Tumors metastasizing to the CNS and leptomeninges (LM) are associated with
significant mortality. We tested the toxicity, pharmacokinetics, and dosimetry of …

In the search for effective therapies against central nervous system (CNS) diseases, it is
questioned whether sufficient intralesional drug concentrations can be reached on systemic …

Abstract 89 Zr-panitumumab is a novel immuno-PET radiotracer. A fully humanized IgG2
antibody, panitumumab binds with high affinity to the extracellular ligand binding domain of …