48 Objectives Previous studies have shown disagreement between in vivo and in vitro
measurements of kinetic parameters in large molecule tracers. For such tracers (like labeled …

549 Objectives Diffusion limitation of antibodies in tissue has been shown to cause depth
penetration problems in tumors. This study aims to investigate the effect of slow diffusion of …

Large-molecule tracers, such as labeled antibodies, have shown success in immuno-PET
for imaging of specific cell surface biomarkers. However, previous work has shown that …

Learning Objectives: On successful completion of this activity, participants should be able to
(1) describe examples of the application of PET tracer kinetic analysis to oncology;(2) list …

Diagnostic nuclear medicine, more recently also named functional molecular imaging, deals
with medical procedures performed to help diagnose a variety of diseases. The procedures …

for five †††Inradiopharmaceuticals and agents used for labeling. While the overall
activity distributions were similar with the greatest concentra tions in the rapidly dividing …

We have previously developed a model that provides relative dosimetry estimates for
targeted radionuclide therapy (TRT) agents. The whole-body and tumor pharmacokinetic …

Molecular imaging of radiotracer distribution by PET or SPECT studies permits the
measurement of the time course of uptake and clearance of specific tracers from different …

Purpose Antibodies form an important class of cancer therapeutics, and there is intense
interest in using them for imaging applications in diagnosis and monitoring of cancer …

Predicting biologic response after incorporation of radioactivity largely relies on calculating
the absorbed dose. Traditionally, dosimetry has been performed using the mean absorbed …