Intratumoral spatial distribution of hypoxia and angiogenesis assessed by 18F-FAZA and 125I-Gluco-RGD autoradiography
M Picchio, R Beck, R Haubner, S Seidl… - Journal of Nuclear …, 2008 - Soc Nuclear Med
The hypoxia-inducible factor-1α (HIF-1α) activates angiogenesis in response to cellular
hypoxia, suggesting a spatial correlation between angiogenesis and tissue hypoxia …
hypoxia, suggesting a spatial correlation between angiogenesis and tissue hypoxia …
Noninvasive molecular imaging of hypoxia in human xenografts: comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markers
F He, X Deng, B Wen, Y Liu, X Sun, L Xing, A Minami… - Cancer research, 2008 - AACR
Tumor hypoxia is important in the development and treatment of human cancers. We have
developed a novel xenograft model for studying and imaging of hypoxia-induced gene …
developed a novel xenograft model for studying and imaging of hypoxia-induced gene …
Correlative imaging of hypoxia and angiogenesis in oncology
KJ Langen, SM Eschmann - Journal of Nuclear Medicine, 2008 - Soc Nuclear Med
Hypoxia plays a critical role in tumor development and aggressiveness and is an important
prognostic factor for resistance to antineoplastic treatments. Hypoxic cells in tumors are …
prognostic factor for resistance to antineoplastic treatments. Hypoxic cells in tumors are …
Rapid detection of hypoxia-inducible factor-1-active tumours: pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible factor-1α
M Ueda, T Kudo, Y Kuge, T Mukai, S Tanaka… - European journal of …, 2010 - Springer
Abstract Purpose Hypoxia-inducible factor-1 (HIF-1) plays an important role in malignant
tumour progression. For the imaging of HIF-1-active tumours, we previously developed a …
tumour progression. For the imaging of HIF-1-active tumours, we previously developed a …
Measurement of tumor hypoxia in patients with advanced pancreatic cancer based on 18F-fluoroazomyin arabinoside uptake
C Metran-Nascente, I Yeung, DC Vines… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Pancreatic cancers are thought to be unusually hypoxic, which might sensitize them to drugs
that are activated under hypoxic conditions. In order to develop this idea in the clinic, a …
that are activated under hypoxic conditions. In order to develop this idea in the clinic, a …
Hypoxia-specific tumor imaging with 18F-fluoroazomycin arabinoside
M Piert, HJ Machulla, M Picchio, G Reischl… - Journal of Nuclear …, 2005 - Soc Nuclear Med
The study was performed to compare the 18F-labeled nitroimidazole compound
fluoroazomycin arabinoside (18F-FAZA) with the standard hypoxia tracer fluoromisonidazole …
fluoroazomycin arabinoside (18F-FAZA) with the standard hypoxia tracer fluoromisonidazole …
In vivo characterization of a reporter gene system for imaging hypoxia-induced gene expression
S Carlin, A Pugachev, X Sun, S Burke, F Claus… - Nuclear medicine and …, 2009 - Elsevier
PURPOSE: To characterize a tumor model containing a hypoxia-inducible reporter gene
and to demonstrate utility by comparison of reporter gene expression to the uptake and …
and to demonstrate utility by comparison of reporter gene expression to the uptake and …
In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1α, a promoter that protects cells, in response to chemotherapy
RJ Viola, JM Provenzale, F Li, CY Li… - American Journal of …, 2008 - Am Roentgen Ray Soc
OBJECTIVE. Bioluminescence imaging is a powerful technique that has shown that hypoxia-
inducible factor 1 (HIF-1), a transcription factor that protects tumor cells from hypoxia, is up …
inducible factor 1 (HIF-1), a transcription factor that protects tumor cells from hypoxia, is up …
Detection of hypoxia in microscopic tumors using 131I-labeled iodo-azomycin galactopyranoside (131I-IAZGP) digital autoradiography
XF Li, X Sun, Y Ma, M Suehiro, M Zhang… - European journal of …, 2010 - Springer
Purpose Previous studies have shown that tumors less than 1 mm diameter derived from
HT29 colorectal cancer cells are extremely hypoxic when grown intraperitoneally or …
HT29 colorectal cancer cells are extremely hypoxic when grown intraperitoneally or …
Imaging hypoxia in tumors
JR Ballinger - Seminars in nuclear medicine, 2001 - Elsevier
For many years, it has been known that hypoxia affects the response to radiotherapy in
human cancers. Hypoxic regions can develop as a tumor grows beyond the ability of its …
human cancers. Hypoxic regions can develop as a tumor grows beyond the ability of its …