TO THE EDITOR: We have enthusiastically read the meticulous and well-conducted
retrospective study by Bauckneht et al. published in the October issue of The Journal of …

1 Doxorubicin effect on myocardial metabolism as a pre-requisite for subsequent
development of cardiac toxicity: a translational Page 1 1 Doxorubicin effect on myocardial …

REPLY: We are grateful to Finessi et al. for their letter which raises a crucial topic. We agree
that many possible confounding factors may challenge the interplay between anthracycline …

The present translational study aimed to verify whether serial 18F-FDG PET/CT predicts
doxorubicin cardiotoxicity. Methods: Fifteen athymic mice were treated intravenously with …

1773 Objectives The anti-tumor effect of doxorubicin (DOX), a glycosidic anthracyclin, linked
to inhibition of Topoisomerase II interacts with cell membranes. Chemotherapy with DOX is …

TO THE EDITOR: We read with great interest the recent article by Rahbar et al. titled
“Differentiation of Malignant and Benign Cardiac Tumors Using 18F-FDG PET/CT”(1). The …

TO THE EDITOR: Recently, Inglese et al. documented an extreme variability in the spatial
and temporal heterogeneity of regional myocardial uptake on repeated whole-body 18F …

Abstract To the Editor: The February 8 issue of the Journal contained an article by Alexander
et al. 1 and an editorial by Henderson and Frei 2 on the cardiotoxicity of doxorubicin. Both …

Background Oxidative stress and its interference on myocardial metabolism play a major
role in Doxorubicin (DXR) cardiotoxic cascade. Methods Mice models of neuroblastoma …

51 Objectives: Cardiotoxicity is a common complication of doxorubicin-based chemotherapy,
limiting the use of this otherwise effective chemotherapeutic. 1 Current approaches to …