188Re-ZHER2: V2, a promising affibody-based targeting agent against HER2-expressing tumors: preclinical assessment
M Altai, H Wållberg, H Honarvar, J Strand… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Affibody molecules are small (7 kDa) nonimmunoglobulin scaffold proteins with favorable
tumor-targeting properties. Studies concerning the influence of chelators on biodistribution …
tumor-targeting properties. Studies concerning the influence of chelators on biodistribution …
Targeting of HER2-expressing tumors with a site-specifically 99mTc-labeled recombinant affibody molecule, ZHER2: 2395, with C-terminally engineered cysteine
S Ahlgren, H Wållberg, TA Tran… - Journal of Nuclear …, 2009 - Soc Nuclear Med
The detection of human epidermal growth factor receptor type 2 (HER2) expression in
malignant tumors provides important information influencing patient management …
malignant tumors provides important information influencing patient management …
[HTML][HTML] Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule 188Re-ZHER2:41071
HER2-targeted radionuclide therapy might be helpful for the treatment of breast, gastric, and
ovarian cancers which have developed resistance to antibody and antibody-drug conjugate …
ovarian cancers which have developed resistance to antibody and antibody-drug conjugate …
Molecular design and optimization of 99mTc-labeled recombinant affibody molecules improves their biodistribution and imaging properties
Affibody molecules are a recently developed class of targeting proteins based on a
nonimmunoglobulin scaffold. The small size (7 kDa) and subnanomolar affinity of Affibody …
nonimmunoglobulin scaffold. The small size (7 kDa) and subnanomolar affinity of Affibody …
Radionuclide Therapy of HER2-Positive Microxenografts Using a 177Lu-Labeled HER2-Specific Affibody Molecule
A radiolabeled anti-HER2 Affibody molecule (ZHER2: 342) targets HER2-expressing
xenografts with high selectivity and gives good imaging contrast. However, the small size (∼ …
xenografts with high selectivity and gives good imaging contrast. However, the small size (∼ …
186Re-maSGS-ZHER2:342, a potential Affibody conjugate for systemic therapy of HER2-expressing tumours
Purpose Affibody molecules are a novel class of tumour-targeting proteins, which combine
small size (7 kDa) and picomolar affinities. The Affibody molecule Z HER2: 342 has been …
small size (7 kDa) and picomolar affinities. The Affibody molecule Z HER2: 342 has been …
[HTML][HTML] Selection of an optimal cysteine-containing peptide-based chelator for labeling of affibody molecules with 188Re
M Altai, H Honarvar, H Wållberg, J Strand… - European Journal of …, 2014 - Elsevier
Affibody molecules constitute a class of small (7 kDa) scaffold proteins that can be
engineered to have excellent tumor targeting properties. High reabsorption in kidneys …
engineered to have excellent tumor targeting properties. High reabsorption in kidneys …
Influence of valency and labelling chemistry on in vivo targeting using radioiodinated HER2-binding Affibody molecules
V Tolmachev, E Mume, S Sjöberg, FY Frejd… - European journal of …, 2009 - Springer
Purpose HER2 is a transmembrane tyrosine kinase, which is overexpressed in a number of
carcinomas. The Affibody molecule Z HER2: 342 is a small (7 kDa) affinity protein binding to …
carcinomas. The Affibody molecule Z HER2: 342 is a small (7 kDa) affinity protein binding to …
Affibody-mediated tumour targeting of HER-2 expressing xenografts in mice
AC Steffen, A Orlova, M Wikman, FY Nilsson… - European journal of …, 2006 - Springer
Purpose Targeted delivery of radionuclides for diagnostic and therapeutic applications has
until recently largely been limited to receptor ligands, antibodies and antibody-derived …
until recently largely been limited to receptor ligands, antibodies and antibody-derived …
Three methods for 18F labeling of the HER2-binding affibody molecule ZHER2: 2891 including preclinical assessment
M Glaser, P Iveson, S Hoppmann… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Human epidermal growth factor receptor (HER2)–targeted Affibody molecules radiolabeled
with 18F allow the noninvasive assessment of HER2 status in vivo through PET imaging …
with 18F allow the noninvasive assessment of HER2 status in vivo through PET imaging …