Systemic COMT inhibition enables the D1 agonist radiotracer [11C]-(R)-SKF82957
1185 Objectives The catechol D1 agonist,[11 C]-(R)-SKF82957,([11 C]-SKF), is metabolised
to a labelled, lipophilic, brain penetrating metabolite, limiting its use as a radiotracer for …
to a labelled, lipophilic, brain penetrating metabolite, limiting its use as a radiotracer for …
Systemic catechol-O-methyl transferase inhibition enables the D1 agonist radiotracer R-[11C] SKF 82957
M Palner, P McCormick, J Parkes, GM Knudsen… - Nuclear medicine and …, 2010 - Elsevier
INTRODUCTION: R-[11C]-SKF 82957 is a high-affinity and potent dopamine D1 receptor
agonist radioligand, which gives rise to a brain-penetrant lipophilic metabolite. In this study …
agonist radioligand, which gives rise to a brain-penetrant lipophilic metabolite. In this study …
[11C] NNC 22-0215, a metabolically stable dopamine D1 radioligand for PET
C Foged, C Halldin, CG Swahn, N Ginovart… - Nuclear medicine and …, 1998 - Elsevier
NNC 22-0215 has been found to be a metabolically stable dopamine D1 antagonist with
high affinity and selectivity for D1 receptors in vitro. We prepared [11C] NNC 22-0215 with a …
high affinity and selectivity for D1 receptors in vitro. We prepared [11C] NNC 22-0215 with a …
In vivo binding of [11C] SKF 75670 and [11C] SKF 82957 in rat brain: two dopamine D-1 receptor agonist ligands
JN DaSilva, AA Wilson, CM Valante, D Hussey… - Life sciences, 1996 - Elsevier
The high affinity benzazepine D1 agonists SKF 75670 and SKF 82957 labeled with C-11
were evaluated in vivo in rats as potential radioligands for imaging dopamine D1 receptors …
were evaluated in vivo in rats as potential radioligands for imaging dopamine D1 receptors …
In vivo evaluation of the D¦ 1 agonist PET ligand R-[¹¹C] SKF 82957, metabolism and regional brain distribution in animal models and humans
RA Schwartz - 1999 - library-archives.canada.ca
Abstract'Rationale'. The dopamine D1 receptor high-affinity (D1HIGH) state is believed to be
the functional state of the receptor coupled to the G protein. Only agonist or partial agonist …
the functional state of the receptor coupled to the G protein. Only agonist or partial agonist …
11C-and 76Br-labelled NNC 22-0010, selective dopamine D1 receptor radioligands for PET
C Foged, C Halldin, C Loc'h, B Mazière… - Nuclear medicine and …, 1996 - Elsevier
NNC 22-0010 is a new dopamine antagonist with a high affinity and selectivity for D1
receptors in vitro. NNC 22-0010 has both an N-methyl group and a bromine, which allows …
receptors in vitro. NNC 22-0010 has both an N-methyl group and a bromine, which allows …
Synthesis and in vivo evaluation of a C-11 labeled novel dopamine D1 receptor agonist radioligand in baboon
B Easwaramoorthy, R Neelamegam, M Palatnik… - 2011 - Soc Nuclear Med
1171 Objectives Currently, the antagonists 11 C-SCH23390 and 11 C-NNC112 are the only
available PET tracers for imaging dopamine D1 receptors (D1R). Neither is selective for …
available PET tracers for imaging dopamine D1 receptors (D1R). Neither is selective for …
18F-rFDGSCH: A novel Fluorine-18 PET imaging agent for Dopamine D1 Receptors
A Baranwal, J Mukherjee - 2015 - Soc Nuclear Med
1049 Objectives The neurological dopamine system is important for reward administration
and transmission of signals between brain regions. Significant impairment has been …
and transmission of signals between brain regions. Significant impairment has been …
18F-MCL-524, an 18F-labeled dopamine D2 and D3 receptor agonist sensitive to dopamine: a preliminary PET study
SJ Finnema, V Stepanov, R Nakao… - Journal of Nuclear …, 2014 - Soc Nuclear Med
PET has been used to examine changes in neurotransmitter concentrations in the living
brain. Pioneering PET studies on the dopamine system have used D2 and D3 receptor …
brain. Pioneering PET studies on the dopamine system have used D2 and D3 receptor …
Dopamine D2-receptor density in humans as assessed with SPET and the new high-affinity ligand 123I-NCQ298: A pilot study
E RYDING, EVA TUNINGER, T OHLSSON… - Nuclear medicine …, 1998 - journals.lww.com
Abstract Astra (S)-3-[123 I] iodo-5, 6-dimethoxyl-N-[(1-ethyl-2-pyrrolidinyl) methyl]-
salicylamide (123 I-NCQ298) is a new high-affinity D2-receptor ligand for use in single …
salicylamide (123 I-NCQ298) is a new high-affinity D2-receptor ligand for use in single …