357 Objectives: The kappa opioid receptor (KOR) has been implicated in various
neuropsychiatric disorders. We have previously developed KOR agonist (11 C …

577 Objectives: The kappa opioid receptor (KOR) has been implicated in various
neuropsychiatric disorders. We have previously evaluated a pair of PET radiotracers for …

The κ-opioid receptor (KOR) is implicated in various neuropsychiatric disorders. We
previously evaluated an agonist tracer, 11C-GR103545, for PET imaging of KOR in humans …

102 Objectives We have developed [11 C] LY2795050 as a novel, selective antagonist PET
tracer for the kappa opioid receptors (KOR) and demonstrated its suitability to image KOR in …

Kappa-opioid receptors (KOR) are believed to be involved in the pathophysiology of
depression, anxiety disorders, drug abuse, and alcoholism. To date, only 1 tracer, the KOR …

Introduction Kappa opioid receptors (KOR) are implicated in several brain disorders. In this
report, a first-in-human positron emission tomography (PET) study was conducted with the …

The κ-opioid receptors (KOR) are involved in mood disorders and addictive conditions. In
vivo imaging studies of this receptor in humans have not been reported because of the lack …

Studies have shown κ-opioid receptor (KOR) abnormalities in addictive disorders, other
central nervous system diseases, and Alzheimer's disease. We have developed the first set …

11C-LY2795050 is a new antagonist PET radioligand for the κ opioid receptor (KOR). In this
study, we assessed the reproducibility of the binding parameters of 11C-LY2795050 in …

The κ-opioid receptor (KOR) has been implicated in depression, addictions, and other
central nervous system disorders and, thus, is an important target for drug development. We …