Dynamic small-animal PET imaging of tumor proliferation with 3′-deoxy-3′-18F-fluorothymidine in a genetically engineered mouse model of high-grade gliomas
MS Bradbury, D Hambardzumyan… - Journal of Nuclear …, 2008 - Soc Nuclear Med
3′-Deoxy-3′-18F-fluorothymidine (18F-FLT), a partially metabolized thymidine analog,
has been used in preclinical and clinical settings for the diagnostic evaluation and …
has been used in preclinical and clinical settings for the diagnostic evaluation and …
18F-fluorothymidine kinetics of malignant brain tumors
C Schiepers, W Chen, M Dahlbom, T Cloughesy… - European journal of …, 2007 - Springer
Purpose 18 F-labeled deoxy-fluorothymidine (FLT), a marker of cellular proliferation, has
been used in PET tumor imaging. Here, the FLT kinetics of malignant brain tumors were …
been used in PET tumor imaging. Here, the FLT kinetics of malignant brain tumors were …
Kinetic analysis of 3′-deoxy-3′-18F-fluorothymidine in patients with gliomas
M Muzi, AM Spence, F O'Sullivan… - Journal of Nuclear …, 2006 - Soc Nuclear Med
3′-Deoxy-3′-fluorothymidine (FLT), a thymidine analog, is under investigation for
monitoring cellular proliferation in gliomas, a potential measure of disease progression and …
monitoring cellular proliferation in gliomas, a potential measure of disease progression and …
[HTML][HTML] Noninvasive quantification of 18F-FLT human brain PET for the assessment of tumour proliferation in patients with high-grade glioma
H Backes, R Ullrich, B Neumaier, L Kracht… - European journal of …, 2009 - Springer
Purpose Compartmental modelling of 3′-deoxy-3′-[18 F]-fluorothymidine (18 F-FLT) PET-
derived kinetics provides a method for noninvasive assessment of the proliferation rate of …
derived kinetics provides a method for noninvasive assessment of the proliferation rate of …
Kinetic modeling of 3′-deoxy-3′-18F-fluorothymidine for quantitative cell proliferation imaging in subcutaneous tumor models in mice
SJ Kim, JS Lee, KC Im, SY Kim, SA Park… - Journal of Nuclear …, 2008 - Soc Nuclear Med
3′-Deoxy-3′-18F-fluorothymidine (18F-FLT) is a thymidine analog that was developed for
measuring tumor proliferation with PET. The aim of this study was to establish a kinetic …
measuring tumor proliferation with PET. The aim of this study was to establish a kinetic …
[18F]FLT PET for Non-Invasive Monitoring of Early Response to Gene Therapy in Experimental Gliomas
MA Rueger, M Ameli, H Li, A Winkeler… - Molecular Imaging and …, 2011 - Springer
The purpose of this study was to investigate the potential of 3′-deoxy-3′-[18 F]
fluorothymidine ([18 F] FLT) positron emission tomography (PET) to detect early treatment …
fluorothymidine ([18 F] FLT) positron emission tomography (PET) to detect early treatment …
Imaging proliferation in brain tumors with 18F-FLT PET: comparison with 18F-FDG
W Chen, T Cloughesy, N Kamdar… - Journal of Nuclear …, 2005 - Soc Nuclear Med
3′-Deoxy-3′-18F-fluorothymidine (18F-FLT) is a recently developed PET tracer to image
tumor cell proliferation. We characterized 18F-FLT PET of brain gliomas and compared 18F …
tumor cell proliferation. We characterized 18F-FLT PET of brain gliomas and compared 18F …
[HTML][HTML] 18F-Fluorothymidine-Pet Imaging of Glioblastoma Multiforme: Effects of Radiation Therapy on Radiotracer Uptake and Molecular Biomarker Patterns
S Chandrasekaran, A Hollander, X Xu… - The Scientific World …, 2013 - hindawi.com
Introduction. PET imaging is a useful clinical tool for studying tumor progression and
treatment effects. Conventional 18 F-FDG-PET imaging is of limited usefulness for imaging …
treatment effects. Conventional 18 F-FDG-PET imaging is of limited usefulness for imaging …
[18F]FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells
CC Zhang, Z Yan, W Li, K Kuszpit, CL Painter… - Clinical Cancer …, 2012 - AACR
Abstract Purpose:[18F] FLT (3′-Fluoro-3′ deoxythymidine)–PET imaging was proposed
as a tool for measuring in vivo tumor cell proliferation. The aim of this article was to validate …
as a tool for measuring in vivo tumor cell proliferation. The aim of this article was to validate …
[HTML][HTML] Toxicology evaluation of radiotracer doses of 3'-deoxy-3'-[18F]fluorothymidine (18F-FLT) for human PET imaging: Laboratory analysis of serial blood …
E Turcotte, LW Wiens, JR Grierson, LM Peterson… - BMC nuclear …, 2007 - Springer
Background 18 F-FLT is a novel PET radiotracer which has demonstrated a strong potential
utility for imaging cellular proliferation in human tumors in vivo. To facilitate future regulatory …
utility for imaging cellular proliferation in human tumors in vivo. To facilitate future regulatory …