Biodistribution and radiation dosimetry of 18F-fluoro-A-85380 in healthy volunteers
M Bottlaender, H Valette, D Roumenov… - Journal of Nuclear …, 2003 - Soc Nuclear Med
This study reports on the biodistribution and radiation dosimetry of 2-18F-Fluoro-3-[2 (S)-2-
azetidinylmethoxy] pyridine (18F-fluoro-A-85380), a promising radioligand for the imaging of …
azetidinylmethoxy] pyridine (18F-fluoro-A-85380), a promising radioligand for the imaging of …
5-[123I]Iodo-A-85380: assessment of pharmacological safety, radiation dosimetry and SPECT imaging of brain nicotinic receptors in healthy human subjects
M Ueda, Y Iida, T Mukai, M Mamede, K Ishizu… - Annals of nuclear …, 2004 - Springer
Abstract Recently, 5-[123 I] iodo-3-(2 (S)-azetidinylmethoxy) pyridine ([123 I] 5IA) was
developed as a ligand for imaging the nicotinic acetylcholine receptor (nAChR) in human …
developed as a ligand for imaging the nicotinic acetylcholine receptor (nAChR) in human …
Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123I]5-IA-85380 in healthy human subjects
The biodistribution of radioactivity after the administration of a new tracer for α4β2 nicotinic
acetylcholine receptors (nAChRs),[123 I] 5-iodo-3-[2 (S)-2-azetidinylmethoxy] pyridine (5-IA …
acetylcholine receptors (nAChRs),[123 I] 5-iodo-3-[2 (S)-2-azetidinylmethoxy] pyridine (5-IA …
Synthesis and evaluation of 6-[18F] fluoro-3-(2 (S)-azetidinylmethoxy) pyridine as a PET tracer for nicotinic acetylcholine receptors
YS Ding, N Liu, T Wang, J Marecek, V Garza… - Nuclear medicine and …, 2000 - Elsevier
Both ABT-594 ((R)-2-chloro-5-(2-azetidinylmethoxy) pyridine) and A-85380 (3-[2 (S)-2-
azetidinylmethoxy] pyridine), novel nicotinic agonists that possess potent non-opioid …
azetidinylmethoxy] pyridine), novel nicotinic agonists that possess potent non-opioid …
In vivo imaging of human cerebral nicotinic acetylcholine receptors with 2-18F-fluoro-A-85380 and PET
JD Gallezot, M Bottlaender, MC Grégoire… - Journal of Nuclear …, 2005 - Soc Nuclear Med
2-18F-Fluoro-3-[2 (S)-2-azetidinylmethoxy] pyridine (2-18F-fluoro-A-85380) is a PET
radioligand that is specific for nicotinic acetylcholine receptors (nAChRs) and has a high …
radioligand that is specific for nicotinic acetylcholine receptors (nAChRs) and has a high …
Whole-body radiation dosimetry of 2-[18F] Fluoro-A-85380 in human PET imaging studies
2-[18F] Fluoro-A-85380 (2-[18F] fluoro-3-(2 (S)-azetidinylmethoxy) pyridine, 2-[18F] FA) is a
recently developed PET radioligand for noninvasive imaging of nicotinic acetylcholine …
recently developed PET radioligand for noninvasive imaging of nicotinic acetylcholine …
Measurement of plasma metabolites of (S)-5-[123I] iodo-3-(2-azetidinylmethoxy) pyridine (5-IA-85380), a nicotinic acetylcholine receptor imaging agent, in nonhuman …
SS Zoghbi, G Tamagnan, M Fujita, RM Baldwin… - Nuclear medicine and …, 2001 - Elsevier
The iodinated analog (S)-5-[123I] iodo-3-(2-azetidinylmethoxy) pyridine of A-85380 is a new
potential SPECT tracer specific for the α4β2 subtype nicotinic acetylcholine receptors, which …
potential SPECT tracer specific for the α4β2 subtype nicotinic acetylcholine receptors, which …
Synthesis of 2‐[18F]fluoro‐3‐[2(S)‐2‐azetidinylmethoxy]pyridine, a highly potent radioligand for in vivo imaging central nicotinic acetylcholine receptors
F Dolle, H Valette, M Bottlaender… - Journal of Labelled …, 1998 - Wiley Online Library
This paper reports the synthesis of 2‐fluoro‐3‐[2 (S)‐2‐azetidinylmethoxy] pyridine and its
radiolabeling with fluorine‐18 ([18F] FK‐K222) by nucleophilic aromatic nitro‐to‐fluoro …
radiolabeling with fluorine‐18 ([18F] FK‐K222) by nucleophilic aromatic nitro‐to‐fluoro …
Radiosynthesis and preliminary evaluation of 5-[123/125I] iodo-3-(2 (S)-azetidinylmethoxy) pyridine: a radioligand for nicotinic acetylcholine receptors
AG Horti, AO Koren, KS Lee, AG Mukhin… - Nuclear medicine and …, 1999 - Elsevier
The radiochemical syntheses of 5-[125I] iodo-3-(2 (S)-azetidinylmethoxy) pyridine (5-[125I]-
iodo-A-85380,[125I] 1) and 5-[123I]-iodo-A-85380,[123I] 1, were accomplished by …
iodo-A-85380,[125I] 1) and 5-[123I]-iodo-A-85380,[123I] 1, were accomplished by …
[HTML][HTML] Synthesis of an I-123 analog of A-85380 and preliminary SPECT imaging of nicotinic receptors in baboon
JL Musachio, VL Villemagne, UA Scheffel… - Nuclear medicine and …, 1999 - Elsevier
A radiosynthetic method to prepare the nicotinic acetylcholine receptor radioligand (S)-5-
[123I] iodo-3-(2-azetidinylmethoxy) pyridine, 5-IA, has been developed. The two-step …
[123I] iodo-3-(2-azetidinylmethoxy) pyridine, 5-IA, has been developed. The two-step …
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