[PDF][PDF] Bringing VISION to Nuclear Medicine: Accelerating evidence and changing paradigms with theranostics

MS Hofman - Journal of Nuclear Medicine, 2021 - Soc Nuclear Med
(PSMA) as a game-changing target for nuclear medicine at the 2011 European Association
of Nuclear Medicine meeting in Birmingham. The target had been identified 2 decades …

[PDF][PDF] 177Lu-PSMA617 and the VISION trial: one of the greatest success stories in the history of nuclear medicine

J Czernin, J Calais - Journal of Nuclear Medicine, 2021 - Soc Nuclear Med
The recently published results of the VISION trial (1) represent the culmination of
translational research efforts that started in the 1980s and early 1990s with the discovery of …

[PDF][PDF] Nuclear medicine beyond VISION

WP Fendler, K Herrmann, M Eiber - Journal of Nuclear Medicine, 2021 - Soc Nuclear Med
In March 2021, Novartis announced a positive result for both primary endpoints of the
randomized phase III VISION study on 177Lu-PSMA-617 radioligand therapy (RLT). 177Lu …

Acceleration of PSMA-targeted theranostics to the clinic: can common sense prevail?

J Czernin, M Eiber - Journal of Nuclear Medicine, 2017 - Soc Nuclear Med
The success of targeting and exploiting the prostate-specific membrane antigen (PSMA) for
diagnosis and radioligand therapy of prostate cancer has been remarkable. Unlike in early …

[PDF][PDF] PSMA-targeted therapeutics: a tale about law and economics

J Notni - Journal of Nuclear Medicine, 2021 - Soc Nuclear Med
Without any doubt, the breakthrough of prostate-specific membrane antigen (PSMA)
targeting radiopharmaceuticals has stirred up nuclear medicine and radiopharmaceutical …

[PDF][PDF] To scan or not to scan: an unnecessary dilemma for PSMA radioligand therapy

S Srinivas, A Iagaru - Journal of Nuclear Medicine, 2021 - Soc Nuclear Med
The recently presented and published results of the VISION phase III study of 177Lu-
PSMA617 for metastatic castrationresistant prostate cancer (1) are indeed one of the …

[HTML][HTML] Targeting PSMA revolutionizes the role of nuclear medicine in diagnosis and treatment of prostate cancer

WI Luining, MCF Cysouw, D Meijer, NH Hendrikse… - Cancers, 2022 - mdpi.com
Simple Summary Imaging plays a crucial role in the accurate staging of prostate cancer.
Prostate-specific membrane antigen (PSMA) is overexpressed in prostate cancer cells, and …

Current status of PSMA-targeted radioligand therapy in the era of radiopharmaceutical therapy acquiring marketing authorization

SW Oh, M Suh, GJ Cheon - Nuclear Medicine and Molecular Imaging, 2022 - Springer
Prostate-specific membrane antigen (PSMA) is highly expressed in PCa, which gradually
increases in high-grade tumors, metastatic tumors, and tumors nonresponsive to androgen …

[PDF][PDF] Why we did what we did: PSMA PET/CT selection criteria for the VISION trial

PH Kuo, T Benson, R Messmann… - Journal of Nuclear …, 2022 - Soc Nuclear Med
After years of development and many published studies, prostate-specific membrane
antigen–targeted radioligand therapy recently reached a critical milestone on March 23 …

[HTML][HTML] PSMA-targeted theranostics of solid tumors: Applications beyond prostate cancers

S An, G Huang, J Liu, W Wei - European Journal of Nuclear Medicine and …, 2022 - Springer
Prostate-specific membrane antigen (PSMA) is a type II transmembrane protein highly
expressed in almost all stages of prostate cancer (PCa)(> 90%)[1]. PSMA ligands for …