In vivo evaluation of pretargeted 64Cu for tumor imaging and therapy
MR Lewis, M Wang, DB Axworthy… - Journal of Nuclear …, 2003 - Soc Nuclear Med
Pretargeting involves administration of a tumor-targeting monoclonal antibody (mAb)
covalently linked to a molecule having a high-affinity binding site for a rapidly distributed …
covalently linked to a molecule having a high-affinity binding site for a rapidly distributed …
Pretargeted radioimmunotherapy in tumored mice using an in vivo 212Pb/212Bi generator
FM Su, P Beaumier, D Axworthy, R Atcher… - Nuclear medicine and …, 2005 - Elsevier
OBJECTIVE: Pretargeting is the concept that combines optimal delivery of the antibody and
rapid capture and elimination of the radioactivity. In this study, we evaluated the potential of …
rapid capture and elimination of the radioactivity. In this study, we evaluated the potential of …
Biodistribution and dosimetry of pretargeted monoclonal antibody 2D12. 5 and Y-Janus-DOTA in BALB/c mice with KHJJ mouse adenocarcinoma
SP Lubic, DA Goodwin, CF Meares… - Journal of Nuclear …, 2001 - Soc Nuclear Med
Biodistribution and dosimetry of 88Y (and equimolar 90Y) Janus-dodecanetetraacetic acid
(DOTA) were performed using a three-step pretargeting protocol in BALB/c mice bearing …
(DOTA) were performed using a three-step pretargeting protocol in BALB/c mice bearing …
Diabody pretargeting with click chemistry in vivo
SMJ van Duijnhoven, R Rossin… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Radioimmunotherapy and nuclear imaging (immuno-PET/SPECT) of cancer with radiometal-
labeled antibody fragments or peptides is hampered by low tumor-to-kidney ratios because …
labeled antibody fragments or peptides is hampered by low tumor-to-kidney ratios because …
Pretargeted radioimmunotherapy (RIT) with a novel anti-TAG-72 fusion protein
A Forero-Torres, S Shen, H Breitz, RB Sims… - Cancer biotherapy & …, 2005 - liebertpub.com
Pretargeted radioimmunotherapy (RIT) increases the dose of radionuclide delivered to
tumor sites while limiting radiation to normal tissues. The three components in Pretarget® …
tumor sites while limiting radiation to normal tissues. The three components in Pretarget® …
Comparative uptakes and biodistributions of internalizing vs. noninternalizing copper-64 radioimmunoconjugates in cell and animal models of colon cancer
JN Bryan, F Jia, H Mohsin, G Sivaguru… - Nuclear medicine and …, 2005 - Elsevier
Copper-64-labeled monoclonal antibodies (mAbs) have previously demonstrated
unexpectedly effective tumor control in rodent models of cancer at relatively low tumor …
unexpectedly effective tumor control in rodent models of cancer at relatively low tumor …
Efficient 1-step radiolabeling of monoclonal antibodies to high specific activity with 225Ac for α-particle radioimmunotherapy of cancer
WF Maguire, MR McDevitt… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Targeted α-particle radiation using the radioisotope 225Ac is a promising form of therapy for
various types of cancer. Historic obstacles to the use of 225Ac have been the difficulty in …
various types of cancer. Historic obstacles to the use of 225Ac have been the difficulty in …
Biodistribution in tumour-bearing mice of two 90Y-labelled biotins using three-step tumour targeting
M Chinol, G Paganelli, F Sudati… - Nuclear medicine …, 1997 - journals.lww.com
Tumour pretargeting techniques based on a three-step approach with the avidin/biotin
system and associated with the high-energy beta-emitter yttrium-90 (90 Y) have been …
system and associated with the high-energy beta-emitter yttrium-90 (90 Y) have been …
[PDF][PDF] Clinical optimization of pretargeted radioimmunotherapy with antibody-streptavidin conjugate and 90Y-DOTA-biotin
HB Breitz, PL Weiden, PL Beaumier… - Journal of Nuclear …, 2000 - Soc Nuclear Med
Pretargeted radioimmunotherapy (PRIT) was evaluated using an antibody-
streptavidinconjugate, followed by a biotin-galactose humanserumalbuminclearingagentand …
streptavidinconjugate, followed by a biotin-galactose humanserumalbuminclearingagentand …
Pretargeted radioimmunotherapy with a single-chain antibody/streptavidin construct and radiolabeled DOTA-biotin: strategies for reduction of the renal dose
GJ Förster, EB Santos, PM Smith-Jones… - Journal of Nuclear …, 2006 - Soc Nuclear Med
Multistep immune targeting holds great promise for radioimmunodiagnosis and therapy of
cancer. Pretargeting of the tetrameric single-chain, variable-fragment streptavidin construct …
cancer. Pretargeting of the tetrameric single-chain, variable-fragment streptavidin construct …