Tetrazine s-TCO ligation: A simple approach to improve probe's blood circulation?
M Wang, D Svatunek, K Rohlfing, Y Liu, H Wang… - 2016 - Soc Nuclear Med
1090 Objectives During the last decade, numerous peptide-based agents have been
developed and evaluated as PET imaging agents. However, one of the limitations …
developed and evaluated as PET imaging agents. However, one of the limitations …
Tetrazine-TCO Ligation: A Potential Simple Approach to Improve Tumor Uptake through Enhanced Blood Circulation
M Wang, H Wang, CQ Niu, T Zhang, Z Wu… - Bioconjugate …, 2020 - ACS Publications
Targeted imaging via peptides has been extensively investigated for both diagnostic and
therapeutic applications. However, peptides can be cleared out from the blood circulation …
therapeutic applications. However, peptides can be cleared out from the blood circulation …
Improved Metabolic Stability for 18F PET Probes Rapidly Constructed via Tetrazine trans-Cyclooctene Ligation
B Giglio, R Selvaraj, S Liu, W Hui, M Wang, H Yuan… - 2015 - Soc Nuclear Med
220 Objectives The fast kinetics and bioorthogonal nature of the tetrazine trans-cyclooctene
(TCO) ligation makes it a unique tool for PET probe construction. Previously, we have …
(TCO) ligation makes it a unique tool for PET probe construction. Previously, we have …
Triazine-based tool box for developing peptidic PET imaging probes: Syntheses, microfluidic radiolabeling, and structure–Activity evaluation
This study was aimed at developing a triazine-based modular platform for targeted PET
imaging. We synthesized mono-or bis-cyclo (RGDfK) linked triazine-based conjugates …
imaging. We synthesized mono-or bis-cyclo (RGDfK) linked triazine-based conjugates …
Improved Metabolic Stability for 18F PET Probes Rapidly Constructed via Tetrazine trans-Cyclooctene Ligation
R Selvaraj, B Giglio, S Liu, H Wang, M Wang… - Bioconjugate …, 2015 - ACS Publications
The fast kinetics and bioorthogonal nature of the tetrazine trans-cyclooctene (TCO) ligation
makes it a unique tool for PET probe construction. In this study, we report the development of …
makes it a unique tool for PET probe construction. In this study, we report the development of …
[HTML][HTML] Conformationally strained trans-cyclooctene (sTCO) enables the rapid construction of 18F-PET probes via tetrazine ligation
M Wang, D Svatunek, K Rohlfing, Y Liu, H Wang… - Theranostics, 2016 - ncbi.nlm.nih.gov
The bioorthogonal reaction between tetrazines and trans-cyclooctenes is a method for the
rapid construction of F-18 probes for PET imaging. Described here is a second generation …
rapid construction of F-18 probes for PET imaging. Described here is a second generation …
Structure-activity relationship of triazine-based PET imaging probes
1020 Objectives We have developed a triazine-based modular platform, in which a core
molecule can be conveniently linked to targeting groups and bifunctional chelator …
molecule can be conveniently linked to targeting groups and bifunctional chelator …
A new 62Cu generator for high specific activity peptide PET imaging
Z Yue, BY Lu, G Vazquez-Flores, J Yuen, X Zhang… - 2010 - Soc Nuclear Med
254 Objectives A 62 Zn/62 Cu generator was developed capable of providing extremely
high specific activity (SA) doses required for peptide targeted PET imaging of low …
high specific activity (SA) doses required for peptide targeted PET imaging of low …
Proof of principle for the use of 11C-labelled peptides in tumour diagnosis with PET
G Henriksen, M Schottelius, T Poethko… - European Journal of …, 2004 - Springer
Purpose The future significance of peptide radiopharmaceuticals in diagnostic imaging with
PET will be dependent on methodological aspects, as well as other requirements such as …
PET will be dependent on methodological aspects, as well as other requirements such as …
11C-Glycylsarcocine targeting the peptide transporter as a novel PET imaging tracer for cancer detection
K Mitsuoka, S Miyoshi, Y Murakami, M Hiraiwa, A Noda… - 2008 - Soc Nuclear Med
78 Objectives: The objective of the present study was to evaluate radiolabeled analogs of
glycylsarcosine (Gly-Sar) as novel probes for the peptide transporters, PEPT1 and PEPT2 …
glycylsarcosine (Gly-Sar) as novel probes for the peptide transporters, PEPT1 and PEPT2 …