8-[18F] Fluoropenciclovir: an improved reporter probe for imaging HSV1-tk reporter gene expression in vivo using PET
M Iyer, JR Barrio, M Namavari, E Bauer… - Journal of Nuclear …, 2001 - Soc Nuclear Med
We have synthesized and evaluated 8-[18F] fluoropenciclovir (FPCV) and compared it with 8-
[18F] fluoroganciclovir (FGCV) for monitoring the expression of herpes simplex virus type 1 …
[18F] fluoroganciclovir (FGCV) for monitoring the expression of herpes simplex virus type 1 …
[PDF][PDF] Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir
SS Gambhir, JR Barrio, L Wu, M Iyer… - Journal of Nuclear …, 1998 - Soc Nuclear Med
We are developing procedures to repeatedly and noninvasively ¡ magethe expression of
transplanted reporter genes in living ani mals and in patients, using PET. We have …
transplanted reporter genes in living ani mals and in patients, using PET. We have …
Imaging in vivo herpes simplex virus thymidine kinase gene transfer to tumour-bearing rodents using positron emission tomography and [18F]FHPG
R Hustinx, CY Shiue, A Alavi, D McDonald… - European journal of …, 2001 - Springer
Radiolabelled ganciclovir analogues have shown promise as imaging agents to detect
herpes simplex virus thymidine kinase (HSV tk) expression. This study evaluated the use of …
herpes simplex virus thymidine kinase (HSV tk) expression. This study evaluated the use of …
Molecular imaging with 123I-FIAU, 18F-FUdR, 18F-FET, and 18F-FDG for monitoring herpes simplex virus type 1 thymidine kinase and ganciclovir prodrug activation …
HE Wang, HM Yu, RS Liu, M Lin… - Journal of Nuclear …, 2006 - Soc Nuclear Med
The ability to monitor tumor responses during prodrug activation gene therapy and other
anticancer gene therapies is critical for their translation into clinical practice. Previously, we …
anticancer gene therapies is critical for their translation into clinical practice. Previously, we …
18F-FEAU as a radiotracer for herpes simplex virus thymidine kinase gene expression: in-vitro comparison with other PET tracers
AR Buursma, V Rutgers, GAP Hospers… - Nuclear medicine …, 2006 - journals.lww.com
Objective The herpes simplex virus thymidine kinase (HSVtk) gene has frequently been
applied as a reporter gene for monitoring transgene expression in animal models. In clinical …
applied as a reporter gene for monitoring transgene expression in animal models. In clinical …
Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression
The efficacy of 3 radiolabeled probes of current interest for imaging herpes simplex virus
type 1 thymidine kinase (HSV1-tk) expression in vivo with PET, including 124I-or 131I …
type 1 thymidine kinase (HSV1-tk) expression in vivo with PET, including 124I-or 131I …
Comparison of [18F]FHPG and [124/125I]FIAU for imaging herpes simplex virus type 1 thymidine kinase gene expression
P Brust, R Haubner, A Friedrich… - European journal of …, 2001 - Springer
Various radiotracers based on uracil nucleosides (eg [124 I] 2'-fluoro-2'-deoxy-5-iodo-1-β-D-
arabinofuranosyluracil,[124 I] FIAU) and acycloguanosine derivatives (eg [18 F] 9-[(3-fluoro …
arabinofuranosyluracil,[124 I] FIAU) and acycloguanosine derivatives (eg [18 F] 9-[(3-fluoro …
Comparison of [18F]FHBG and [14C]FIAU for imaging of HSV1-tk reporter gene expression: adenoviral infection vs stable transfection
JJ Min, M Iyer, SS Gambhir - European journal of nuclear medicine and …, 2003 - Springer
Earlier studies involving comparison of different reporter probes have shown conflicting
results between pyrimidine nucleosides [eg, 2'-fluoro-2'-deoxy-1-β-d-arabinofuranosyl-5 …
results between pyrimidine nucleosides [eg, 2'-fluoro-2'-deoxy-1-β-d-arabinofuranosyl-5 …
Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography
We are developing quantitative assays to repeatedly and noninvasively image expression of
reporter genes in living animals, using positron emission tomography (PET). We synthesized …
reporter genes in living animals, using positron emission tomography (PET). We synthesized …
A tracer kinetic model for 18F-FHBG for quantitating herpes simplex virus type 1 thymidine kinase reporter gene expression in living animals using PET
LA Green, K Nguyen, B Berenji, M Iyer… - Journal of Nuclear …, 2004 - Soc Nuclear Med
Reporter probe 9-(4-18F-fluoro-3-[hydroxymethyl] butyl) guanine (18F-FHBG) and reporter
gene mutant herpes simplex virus type 1 thymidine kinase (HSV1-sr39tk) have been used …
gene mutant herpes simplex virus type 1 thymidine kinase (HSV1-sr39tk) have been used …