Optical molecular imaging using fluorescently labeled monoclonal antibodies is of
significant added value in guiding surgical or endoscopic procedures. However …

Purpose The development of molecularly targeted tracers is likely to improve the accuracy of
diagnostic, screening, and therapeutic tools. Despite the many therapeutic antibodies that …

Highlights•Monoclonal antibody is a good platform for designing optical molecular imaging
probe.•Conjugation reaction to humanized can be similarly performed.•Optimal florescent …

Rationale: Knowledge on monoclonal antibody biodistribution in healthy tissues in humans
can support clinical drug development. Molecular imaging with positron emission …

Background Photoimmunodetection, in which monoclonal antibodies [mAbs] are labeled
with fluorescent dyes, might have clinical potential for early detection and characterization of …

Clinical production of 89Zr-radiolabeled antibodies (89Zr-mAbs) for positron emission
tomography imaging relies on the pre-conjugation of desferrioxamine B (DFO) to the purified …

Background We describe a new method for biodistribution studies with IRDye800CW
fluorescent antibody probes. This method allows the quantification of the IRDye800CW …

Purpose Intraoperative optical imaging to guide surgeons during oncologic resections offers
a unique and promising solution to the ambiguity of cancer margins to tactile and visual …

Monoclonal antibodies labeled with near-infrared (NIR) fluorophores have potential use in
disease detection, intraoperative imaging, and pharmacokinetic characterization of …

Radiolabeled antibodies (Abs) are an attractive tool for targeting and delivering particle
emitters for therapy or imaging applications. The labeling of Abs with metal radionuclides …