18F-Labeling and evaluation of novel 18F-labelled MDL 100907 derivatives as potential 5-HT2A antagonists
1219 Objectives Beside [18 F] altanserin,[11 C] MDL 100907 is the tracer of choice to image
the 5-HT 2A receptor. The selectivity of MDL 100907 prefers this tracer. Nevertheless, it is …
the 5-HT 2A receptor. The selectivity of MDL 100907 prefers this tracer. Nevertheless, it is …
18F-labeling and evaluation of novel MDL 100907 derivatives as potential 5-HT2A antagonists for molecular imaging
INTRODUCTION: The serotonergic system, especially the 5-HT2A receptor, is involved in
various diseases and conditions. It is a very interesting target for medicinal applications …
various diseases and conditions. It is a very interesting target for medicinal applications …
Synthesis and evaluation of 18F-MDL 100907 derivatives for the 5-HT2A receptor
1228 Objectives: The objective of this study was to develop 18F-analogs of MDL 10007
combining the advantages of the greater selectivity of MDL 100907 over Altanserin and the …
combining the advantages of the greater selectivity of MDL 100907 over Altanserin and the …
Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET
Radiolabelled piperidine derivatives such as [11C] MDL 100907 and [18F] altanserin have
played an important role in diagnosing malfunction in the serotonergic neurotransmission. A …
played an important role in diagnosing malfunction in the serotonergic neurotransmission. A …
Fluorine-18 Labeling of (R)-(+)-MDL100907, a Selective 5-HT2A Receptor Antagonist for PET-Imaging
2828 Introduction: Serotonin receptors, 5HTR, are important in the central nervous system
(CNS) and peripheral tissues and play a crucial role in the pathophysiology of several …
(CNS) and peripheral tissues and play a crucial role in the pathophysiology of several …
Preliminary in vivo and ex vivo evaluation of the 5-HT2A imaging probe [18F] MH. MZ
INTRODUCTION: The 5-HT2A receptor is one of the most interesting targets within the
serotonergic system because it is involved in a number of important physiological processes …
serotonergic system because it is involved in a number of important physiological processes …
Radiopharmacological evaluation of [18F] F13640, a novel 5-HT1A receptor agonist
B Vidal, S Fieux, T Billard, A Newman-Tancredi… - 2014 - Soc Nuclear Med
1100 Objectives Brain serotonin 1A receptors (5-HT1A) exist in high-and low-affinity states. It
is known that agonists bind preferentially to the high-affinity state of the receptor and …
is known that agonists bind preferentially to the high-affinity state of the receptor and …
[18F] Fluoroalkyl analogues of the potent 5-HT1A antagonist WAY 100635: radiosyntheses and in vivo evaluation
AA Wilson, JN DaSilva, S Houle - Nuclear medicine and biology, 1996 - Elsevier
Two analogues of the potent 5-HT1A antagonist WAY 100635 have been synthesized and
radiolabelled with 18F, namely N-[2-[4 (2-2′-[18F] fluoroethoxyphenyl)-1-piperazinyl] ethyl] …
radiolabelled with 18F, namely N-[2-[4 (2-2′-[18F] fluoroethoxyphenyl)-1-piperazinyl] ethyl] …
Synthesis, fluorine-18 labelling and radiopharmacological evaluation of F15599, a novel 5-HT1A receptor agonist
L Lemoine, M Verdurand, B Vacher, E Blanc, D Le Bars… - 2008 - Soc Nuclear Med
1217 Objectives: Brain serotonin 1A receptors (5-HT1A) exist in high-and low-affinity states.
It is known that agonists bind preferentially to the high-affinity state of the receptor and …
It is known that agonists bind preferentially to the high-affinity state of the receptor and …
Synthesis and in vivo evaluation of a novel 5-HT1A receptor agonist [11C] MMP in nonhuman primates
JSD Kumar, J Prabhakaran, M Joseph, M Milak… - 2007 - Soc Nuclear Med
1341 Objectives: 5-HT1A receptors exist in high and low affinity states and agonist ligands
bind preferentially to the high affinity state of the receptor and provide a measure of …
bind preferentially to the high affinity state of the receptor and provide a measure of …