Amyloid Load in the Down syndrome population measured with [11C] PiB PET
251 Background: Individuals with Down syndrome (DS) are at increased risk of developing
Alzheimer's disease (AD) and show the earliest signs of amyloid-β (Aβ) deposition in the …
Alzheimer's disease (AD) and show the earliest signs of amyloid-β (Aβ) deposition in the …
Comparison of Amyloid Beta Accumulation in Down Syndrome and Late Onset Cohorts
A McVea, A DiFilippo, M McLachlan, D Murali, Y Xin… - 2022 - Soc Nuclear Med
2604 Introduction: Down syndrome (DS) is characterized by the triplication of chromosome
21, which contains the gene that encodes for amyloid precursor protein (APP). The …
21, which contains the gene that encodes for amyloid precursor protein (APP). The …
Beta-amyloid accumulates at a faster rate in Down Syndrome than Neurotypical Populations
A McVea, A DiFilippo, M McLachlan, D Murali… - 2023 - Soc Nuclear Med
P493 Introduction: Down syndrome (DS) is characterized by the triplication of chromosome
21, which contains the gene that encodes for amyloid precursor protein (APP). The …
21, which contains the gene that encodes for amyloid precursor protein (APP). The …
Amyloid accumulation in Down syndrome measured with amyloid load
MD Zammit, CM Laymon, TJ Betthauser… - Alzheimer's & …, 2020 - Wiley Online Library
Abstract Introduction Individuals with Down syndrome (DS) show enhanced amyloid beta
(Aβ) deposition in the brain. A new positron emission tomography (PET) index of amyloid …
(Aβ) deposition in the brain. A new positron emission tomography (PET) index of amyloid …
Amyloid load: a more sensitive biomarker for amyloid imaging
A Whittington, RN Gunn - Journal of Nuclear Medicine, 2019 - Soc Nuclear Med
Amyloid-β (Aβ) plays a key role in the pathogenesis of Alzheimer disease (AD) and can be
imaged in vivo using 18F-florbetapir PET. A composite SUV ratio (SUVr) is a commonly used …
imaged in vivo using 18F-florbetapir PET. A composite SUV ratio (SUVr) is a commonly used …
An accelerated rate of Beta‐amyloid Measured with [C‐11] PiB in Down Syndrome compared to Neurotypical Populations
AK McVea, AH DiFilippo, M McLachlan… - Alzheimer's & …, 2023 - Wiley Online Library
Background Down syndrome (DS) is characterized by a higher risk and earlier onset of beta‐
amyloid (Aβ) plaque accumulation and Alzheimer's disease (AD). The triplication of …
amyloid (Aβ) plaque accumulation and Alzheimer's disease (AD). The triplication of …
Neurofibrillary tau emerges in adults with Down syndrome during the earliest stages of Aβ accumulation
M Zammit, A DiFilippo, T Tullis, A McVea, D Tudorascu… - 2021 - Soc Nuclear Med
42 Introduction: Adults with Down syndrome (DS) are genetically predisposed to Alzheimer's
disease (AD) and accumulate beta-amyloid plaques (Aβ) early in life. The aim of this study …
disease (AD) and accumulate beta-amyloid plaques (Aβ) early in life. The aim of this study …
[CITATION][C] IC‐06‐01: ASSESSMENT OF LONGITUDINAL AMYLOID LOAD CHANGE IN DOWN SYNDROME
Background Trisomy of chromosome 21 in Down syndrome results in an overexpression of
the gene encoding amyloid precursor protein and an early presence of β-amyloid plaques in …
the gene encoding amyloid precursor protein and an early presence of β-amyloid plaques in …
Impact of PET reconstruction parameters on the quantitation of PET Aβ-amyloid
3281 Introduction: The commonly employed standardized uptake value ratio (SUVR) and
Centiloid scale (CL) metrics to quantify extracellular Aβ-amyloid (Aβ) plaques are influenced …
Centiloid scale (CL) metrics to quantify extracellular Aβ-amyloid (Aβ) plaques are influenced …
Regional associations between amyloid and glucose metabolism during the progression of Alzheimer's disease in Down syndrome
M Zammit, C Laymon, D Tudorascu, A DiFilippo… - 2020 - Soc Nuclear Med
21 Background: Adults with Down syndrome (DS) carry a triplicate copy of chromosome 21
resulting in the overproduction of amyloid precursor protein, with earliest deposition of Aβ …
resulting in the overproduction of amyloid precursor protein, with earliest deposition of Aβ …
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