21 Background: Adults with Down syndrome (DS) carry a triplicate copy of chromosome 21
resulting in the overproduction of amyloid precursor protein, with earliest deposition of Aβ …

Background: The Down syndrome (DS) population is genetically predisposed to amyloid-
ßprotein precursor overproduction and Alzheimer's disease (AD). Objective: The temporal …

P493 Introduction: Down syndrome (DS) is characterized by the triplication of chromosome
21, which contains the gene that encodes for amyloid precursor protein (APP). The …

2604 Introduction: Down syndrome (DS) is characterized by the triplication of chromosome
21, which contains the gene that encodes for amyloid precursor protein (APP). The …

Abstract Introduction Adults with Down syndrome (DS) are predisposed to Alzheimer's
disease (AD) and the relationship between cognition and glucose metabolism in this …

124 Objectives In Alzheimer's Disease (AD), extracellular beta-amyloid plaques (Aβ) and
intracellular neurofibrillary tangles (tau) represent the primary pathological hallmarks …

Background In the DIAN cohort of individuals from families with autosomal dominant
Alzheimer disease (ADAD), we examined the temporal ordering of amyloid deposition (PIB …

Dysfunctional insulin signaling may affect brain metabolism or amyloid deposition. We
investigated the associations of type 2 diabetes with amyloid accumulation measured using …

Amyloid-β (Aβ) deposition is a pathologic hallmark of Alzheimer disease (AD). Although the
typical spatial distribution pattern of Aβ deposition in early AD mainly involves regions …

Background Although hypometabolism is commonly seen in aging and Alzheimer's disease
(AD), the relationship between glucose metabolism and A β deposition in cognitively normal …