For a PET agent to be successful as a biomarker in early clinical trials of new anticancer
agents, some conditions need to be fulfilled: the selected tracer should show a response that …

BACKGROUND: Molecular targeting has become a prominent concept in cancer treatment
and heat shock protein 90 (Hsp90) inhibitors are suggested as promising anticancer drugs …

We compared 68Ga-DOTA-F (ab′) 2-herceptin (DOTA is 1, 4, 7, 10-tetraazacyclododecane-
N, N′, N ″, N‴-tetraacetic acid [HER2 PET]) and 18F-FDG PET for imaging of tumor …

Paclitaxel is used as a chemotherapy drug for the treatment of various malignancies,
including breast, ovarian, and lung cancers. To evaluate the potential of a noninvasive …

New surrogate end points for monitoring response to cancer treatment are needed for both
current and novel therapeutic strategies. Positron emission tomography (PET) as a …

11076 Background: PU-H71 is a Heat Shock Protein 90 inhibitor that can be labeled with
124I without altering its biochemical properties. Intratumoral drug concentration can be …

Hypoxia is a significant therapeutic problem for solid tumors because hypoxic cells are
treatment-resistant and more aggressive. Hypoxia-activated prodrugs such as SN30000 use …

For molecular targeted cancer therapies to fulfill their promise in cancer treatment,
innovative approaches are required to overcome significant obstacles that exist in the …

Imaging of biological processes using specific molecular probes allows exploration of the
mechanism of action and efficacy for new therapies. This molecular imaging has made use …

The term 'molecular imaging'encompasses a range of imaging techniques that are aimed at
visualizing molecular events at a cellular level in a living organism, in a non-invasive …