Bromodeoxyuridine as a Proliferation Marker Page 1 In Vitro and Animal Validation of
Bromine-76Bromodeoxyuridine as a Proliferation Marker Mats Bergstrom, Li Lu, Karl-Johan …

76Br-bromodeoxyuridine has previously been suggested as a PET tracer to characterize
proliferation potential. However, in animal studies a large fraction of the tissue radioactivity is …

5-bromodeoxyuridine (BUdR) provides in vitro measures of tumor cell proliferation. We used
positron emission tomography to study tissue and plasma kinetics of [76Br] BUdR in tumor …

5-Bromo-2′-deoxyuridine (BrUdR) labeled with 77Br and 76Br was compared with 5-iodo-
2′-deoxyuridine (IUdR) labeled with 125I or 131I, first in vitro then in in vivo experiments in …

This investigation aimed to validate 5-[76Br] bromo-2′-fluoro-2′-deoxyuridine (BFU) as a
proliferation marker using PET. Methods: Five megabecquerels 76Br-BFU were injected into …

Uncontrolled cell proliferation is one of the prominent features in cancer development.
Precise tools are needed for determination of the proliferation rate before, during and after …

[76Br] Bromodeoxyuridine ([76Br] BrdU) might allow a determination of proliferation in vivo
using positron emission tomography (PET), but only with consideration of organ nonspecific …

We analyzed and compared 1-(2′-deoxy-2′-fluoro-β-d-arabinofuranosyl)-[methyl-11C]
thymine (11C-FMAU), 3′-deoxy-3′-[18F] fluorothymidine (18F-FLT) and 1-(2′-deoxy-2 …

The study of cell kinetics is proving to be a cyclical phenomenon. A brief history shows a
pattern of interest and activity similar to a percent labelled mitosis (plm) curve (Fig. 3.1) …

The nucleoside 5-fluoro-2-deoxyuridine is a pyrimidine analogue accumulating in
proliferative cells. We prospectively evaluated biodistribution of the PET tracer [18F] 5-fluoro …