Role of lipid-soluble complexes in targeted tumor therapy

ML Thakur, R Coss, R Howell… - Journal of Nuclear …, 2003 - Soc Nuclear Med
Radionuclide therapy remains a promising arsenal against cancer. However, low tumor
uptake, high radiation dose to normal organs, and subsequent adverse effects are …

New liposome-radionuclide-chelate combination for tumor targeting and rapid healthy tissue clearance

IO Umeda, Y Koike, M Ogata, E Kaneko… - Journal of Controlled …, 2023 - Elsevier
Radionuclide imaging and therapy are promising methods for controlling systemic cancers;
however, their clinical application has been limited by excessive radionuclide accumulation …

Biodistribution and pharmacokinetics of In-111-labeled Stealth {reg_sign} liposomes in patients with solid tumours

KJ Harrington, AM Peters, S Mohammadtaghi - Journal of Nuclear Medicine, 1996 - osti.gov
The use of liposomal doxorubicin yields response rates of up to 70-80% in patients with
AIDS-related Kaposis sarcoma with favourable alteration of the toxicity profile of the drug …

Indium-111-labelled liposomes: dosimetry and tumour detection in patients with cancer

A Kubo, K Nakamura, T Sammiya, M Katayama… - European journal of …, 1993 - Springer
Neutral phospholipid vesicles (VesCan), which had been prepared for clinical use, were
loaded with 37 MBq indium-111 and administered to seven patients with malignant tumours …

Localization of indium-111 in human malignant tumor xenografts and control by chelators

N Watanabe, N Oriuchi, K Endo, T Inoue… - Nuclear medicine and …, 1999 - Elsevier
The kinetics of soluble indium-111 (111In) in human malignant tumor xenografts and cells
was investigated in combination with chelators. Firstly, without chelator, the kinetics of 111In …

[PDF][PDF] Tumor-imaging potential of liposomes loaded with In-111-NTA: biodistribution in mice

RT Proffitt, LE Williams, CA Presant… - Journal of Nuclear …, 1983 - Soc Nuclear Med
MATERIALS AND METHODS Liposome preparation. SUVs containing the ionophore
A23187 were prepared from distearoyl phosphatidyl choline (DSPC), cholesterol (CH) …

Differences in 111In uptake in mouse brain sarcoma based on form of administration

T Konikowski, HJ Glenn, TP Haynie… - International Journal of …, 1977 - Elsevier
It has been shown that when 111 In is injected as the chloride, it largely binds to transferrin.
We studied the biokinetics and distribution of three substances in mice bearing an in situ …

Radioiodination of glycoprotein-conjugated liposomes by using the Bolton-Hunter reagent and biodistribution in tumor-bearing mice

N Shimura, Y Sogawa, Y Kawakita, M Ikekita… - Nuclear medicine and …, 2002 - Elsevier
We have developed a suitable radiolabeling method for our new type of glycoprotein-
liposome conjugate (GCL), in order to investigate its potential utility as a drug carrier that can …

Cholesterol enhances the delivery of liposome-encapsulated gallium-67 to tumors

I Ogihara-Umeda, S Kojima - European journal of nuclear medicine, 1989 - Springer
The effect of incorporation of cholesterol (CH) into liposome membranes on the delivery of
67 Ga encapsulated in liposomes to tumors was studied. The changes of the blood …

A kit formulation for the preparation of 188Re-lipiodol: preclinical studies and preliminary therapeutic evaluation in patients with unresectable hepatocellular …

A Boschi, L Uccelli, A Duatti, P Colamussi… - Nuclear Medicine …, 2004 - journals.lww.com
A lyophilized kit formulation for the efficient labelling of lipiodol with generator-produced
rhenium-188 is described. The preliminary preparation of the lipophilic complex bis …