Physiologic Modeling of PETData:QuantitativeConflict Page 1 T he purpose of in vivo
quantification ofphysiological, biochemical and/or pharmacological processes using PET or …

545 Objectives: We demonstrate a method of analyzing data from a single bolus PET scan
for the purpose of characterizing the temporal profile of neurotransmitter (NT) release …

Quantitative imaging biomarkers are widely used in PET for both research and clinical
applications, yet bias in the underlying image data has not been well characterized. In the …

The possibility of utilizing the PET approach to the investigation of dynamic physiologic
processes has not been limited so far by radiation exposure to the patient but rather …

PET has long been regarded as a quantitative imaging tool. That is, the voxel values of
reconstructed images can be calibrated in absolute units of radioactivity concentration with …

The classical intent of PET imaging is to obtain the most accurate estimate of the amount of
positron-emitting radiotracer in the smallest possible volume element located anywhere in …

Positron emission tomography (PET) is a functional imaging technique that measures the
local concentration of an exogenous tracer molecule in the target tissue. Thus, given a time …

Most PET kinetic modeling approaches have at their basis a compartmental model that has
first-order, constant coefficients. The present article outlines the one-, two-, and three …

In clinical practice, most PET imaging is performed at a single timepoint after tracer injection—
that is,“static” PET imaging. In practice, static [18F]-fluorodeoxyglucose (FDG) PET scans are …

PET quantification begins with knowledge of the radioactivity levels in tissue, which can be
determined accurately only after correction for attenuation and scatter. Further confidence in …