Conclusion: Rv is preferredbecause it providesa theoreticallyvalid estimate of kg/k4,
independently of rCBF or CR. Alternatively, RAmight be preferred to RPEbecause the former …

Methods: Multilinear regression analysis (MLRA) and graphical analysis (GA) using plasma
parent (P) plus metabolite (M) activities as input and time activities of receptor-free (RF …

Abstract 11 C-Raclopride is a widely used positron emission tomography (PET) tracer for
measurement of striatal D 2 dopamine receptor binding characteristics. Recently, 11 C …

Subjectschosen for initial studies were male volunteers (a total of nine, age: 18— 50,
mean= 28) who had no history of prior neurologic or psychiatric disorders. Informed consent …

ÖPECT imaging of dopamine D2-receptors using I23l-labeled benzamide analogs such as
[I23l] iodobenzamide (IBZM) and [I23l] iodobenzofuran (IBF) is a potentially useful tool to …

West Haven, Connecticut and the Division ofNuclear Medicine, University ofPennsylvania
School ofMedicine, Philadelphia, Pennsylvania these conditions. The plasma was …

I f 1 slice). The thirdexperimentwas performedwith striatum-to-back ground and cerebellum-
to-background 1@ Iconcentration ratios varying from 1.2-10.8. The purpose was to …

INTRODUCTION: In vitro, the dopamine D2 receptor exists in two states, with high and low
affinity for agonists. The high-affinity state is the physiologically active state thought to be …

The increasing use of genetically engineered mice as animal models of human disease in
biomedical research, latest advances in imaging technologies, and development of novel …

In this study, we applied a tracer programmedinfusion technique (20, 21) with the SPECT D2
receptor probe [†œ-@ I] IBZM (22) to establish a stable baseline for evaluation of the d …