Both derivativeswere radiolabeledwith †††Inas the acetate to a specificactivityof
approximately20@ Ci/@@ g. The radiochemical purity of the labeledbiotin was routinely …

flammatory lesions via the common mechanism of leaky capillaries. It is in this situation of
equivalent target uptake that the low background oh tamable with pretargeting is a great …

Animal studies of infection imaging by a two-step protocol have shown that important
improvements in target to nontarget ratios are possible. In this protocol, unlabeled …

unintended effect of free avidin administered after the conjugated antibody and before the
labelled biotin. Recent studies have shown that both tumour [13] and infection/inflammation …

MATERIALS AND METHODS The substances used were: N-hydroxysuccinimidobiotin (NHS-
biotin), 2, 4, 6 trinitrobensolsulphoacid (TNBS), Iodo gen (Pierce Chemical Co., Rockford …

Avidin* and Streptavidin* were both conjugated with DTPA using the cyclic anhydride of
DPTA*(13). The proteins were prepared at a concentration of 20 mg/ml in 0.05 M …

The potential of indium-111 labelled diethylenetriaminepentaacetic acid α, ω-bis
(biocytinamide)(111 In-DTPA-Biotin) as a specific tracer in nuclear medicine imaging of …

We describe a new radioligand assay for determining biotin in biological fluids by using a
mixture of N-[beta-(4-OH-3-125I-phenyl) ethyl]-and N-[beta-(4-OH-3, 5-di-125I-phenyl) ethyl] …

Localization of Indium-ill-Immunoglobulin G, Technetium-99m-.Immunoglobulin G and
Indium-ill-Labeled White Blood Cells at Sites Page 1 tion imagingare 67Ga-citrate(2,3), â€â€œIn-labeledleukocytes …

The extraordinary high affinity of avidin and Streptavidin for biotin may be exploited in a two-
step approach for delivering radiolabeled biotin derivatives suitable for imaging and therapy …