The adenosine triphosphate-binding cassette transporters P-glycoprotein (Pgp) and breast
cancer resistance protein (BCRP) are 2 major gatekeepers at the blood–brain barrier (BBB) …

The multidrug efflux transporter P-glycoprotein (P-gp) is expressed in high concentrations at
the blood–brain barrier (BBB) and is believed to be implicated in resistance to central …

Radiolabeled compounds used for brain imaging with PET must readily cross the blood–
brain barrier (BBB) to reach their target. Efflux transporters at the BBB—P-glycoprotein (P …

Brain penetration of radiopharmaceuticals or therapeutic drugs may be restricted by
adenosine triphosphate‐binding cassette (ABC) transporters, such as P‐glycoprotein (Pgp) …

Purpose Overactivity of the multidrug efflux transporter P-glycoprotein (P-gp) at the blood-
brain barrier (BBB) is believed to play an important role in resistance to central nervous …

The permeability-glycoprotein (P-gp) efflux transporter is densely expressed at the blood–
brain barrier, and its resultant spare capacity requires substantial blockade to increase the …

INTRODUCTION: The multidrug efflux transporter breast cancer resistance protein (BCRP)
is highly expressed in the blood-brain barrier (BBB), where it limits brain entry of a broad …

Tariquidar, a potent, nontoxic, third-generation P-glycoprotein (P-gp) inhibitor, is a possible
reversal agent for central nervous system drug resistance. In animal studies, tariquidar has …

Breast cancer resistance protein (BCRP) is the most abundant multidrug efflux transporter at
the human blood–brain barrier (BBB), restricting brain distribution of various drugs. In this …

The effects of metoclopramide on the central nervous system (CNS) in patients suggest
substantial brain distribution. Previous data suggest that metoclopramide brain kinetics may …