PET to neuroimaging research, the determination of the percentage of receptors occupied
by an exogenously administered drug stands out for the immediate and practical information …

We worked over the past several months with an international group of experts in
compartmental modeling and created a consensus nomenclature for in vivo imaging using …

535 Objectives: In terms of the standard PET neuroreceptor model, receptor occupancy (RO)
by an exogenous drug is measured by the fractional decrease in VS, the volume of …

A good understanding of the in vivo pharmacokinetics of radioligands is important for
accurate PET quantification in molecular brain imaging. For many reversibly binding …

Physicians; The Univ. of Michigan, Divi sion of Nuclear Medicine; and the US Dept.
ofEnergy. Location: Hotel des Con verneursLe Grand, Montreal, Canada …

The testing of putative receptor-binding radiotracers in vivo is one of the most complicated
tasks in radiopharmaceutical chemistry. This chapter proposes a series of tests that define a …

Dear Sir, Before a new radioactive tracer can be used in humans, many national as well as
local Institutional Radiation Safety Committees often require that a biodistribution study be …

The non-specific binding of radioligands to tissue, both in vivo and in vitro, is poorly
understood and is a phenomenon that is a major confounding factor in the development of …

Dear Sir, We read with interest the commentary by Hirvonen et al.[1] on the quantification of
radioligands with slow kinetics. Their critique of our work on the quantification of the type 1 …

With the stated aim of scanning small regions of interest in mice, several high-resolution
positron emission tomographic (PET) systems are presently under development. Some …