The Continuing Education article by Spagnoli et al. on pages 1800–1815 of this issue of The
Journal of Nuclear Medicine (1) provides an excellent review of the pathophysiology of …

Atheromas are very prevalent in humans at autopsy. Most of the lesions are found in the
aorta and in the carotid, iliac, and coronary arteries. Histologic studies have demonstrated …

Notwithstanding the major improvements in diagnosis and therapy, coronary heart disease
remains the leading cause of death in the United States. About every 26 s, an American will …

In recent years, various clinical observations have emphasized the need for a more detailed
analysis of atherosclerotic plaques. Information beyond the resulting degree of narrowing of …

In the preceding decade, angiogenesis has been evaluated as a promising therapeutic
option for patients with endstage coronary artery disease [1, 2]. Angiogenesis in …

Despite primary and secondary prevention, serious cardiovascular events such as unstable
angina or myocardial infarction still account for one-third of all deaths worldwide. Therefore …

Coronary artery disease is the most important cardiovascular health problem of the past
century [1, 2], and threatens to continue to be the major cause of morbidity and mortality in …

Traditional imaging modalities used in the assessment of atherosclerotic plaque have
focused on anatomic characteristics of size, location and luminal encroachment. The ability …

Atherosclerosis is a systemic disease that involves coronary arteries as well as large
arteries, such as major branches of the aorta and carotid arteries. Epidemiologic studies …

It is now realized that atherosclerotic plaques do not always impinge on lumen diameter and
that clinical events due to plaque rupture, such as myocardial infarction and stroke, occur …