Animal models have been instrumental in elucidating key biochemical and physiologic
processes of cancer onset and propagation in a living organism. Most importantly, they have …

Preclinical models of human cancers are indispensable in the drug discovery and
development process for new cancer drugs, small molecules and biologics. They are …

Genetically engineered mouse models have significantly contributed to our understanding of
cancer biology. They have proven to be useful in validating gene functions, identifying novel …

Cancer is the term used to describe over 100 diseases that share several common
hallmarks. Despite prevention, early detection, and novel therapies, cancer is still the …

Mouse models of human cancer have played a vital role in understanding tumorigenesis
and answering experimental questions that other systems cannot address. Advances …

Selection of mouse models of cancer is often based simply on availability of a mouse strain
and a known compatible tumor. Frequently this results in use of tumor models long on …

Cancer is a major stress for public well‐being and is the most dreadful disease. The models
used in the discovery of cancer treatment are continuously changing and extending toward …

Laboratory mice have represented a powerful experimental system for understanding the
intricacy of human cancer pathogenesis. Indeed, much of our current conceptualization of …

Significant advances have been made in developing novel therapeutics for cancer
treatment, and targeted therapies have revolutionized the treatment of some cancers …

Through scientific and technological advancements, our ability to manipulate the mouse
genome has allowed us to evaluate the effect of specific genetic alterations on in vivo …