Determination of an optimal pharmacokinetic model of 18F-FET for quantitative applications in rat brain tumors

MA Richard, JP Fouquet, R Lebel… - Journal of Nuclear …, 2017 - Soc Nuclear Med
O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) is a radiolabeled artificial amino acid used in PET
for tumor delineation and grading. The present study compares different kinetic models to …

[HTML][HTML] Evaluation of factors influencing 18F-FET uptake in the brain

A Verger, C Stegmayr, N Galldiks, A Van Der Gucht… - NeuroImage: Clinical, 2018 - Elsevier
PET using the amino-acid O-(2-18 F-fluoroethyl)-l-tyrosine (18 F-FET) is gaining increasing
interest for brain tumour management. Semi-quantitative analysis of tracer uptake in brain …

O-(2-[18F]fluoroethyl)-l-tyrosine (18F-FET) Uptake in Mouse Thymoma Cells, and Its Biodistribution in Mice and Human Volunteers

K Abe, K Hayashi, M Sasaki, H Koga, K Kaneko… - Acta …, 2006 - Taylor & Francis
Purpose: To evaluate O-(2-[18F] fluoroethyl)-l-tyrosine (18F-FET) uptake in mouse malignant
thymoma (EL4), and its biodistribution in mice and humans. Material and Methods: First, 18F …

Current trends in the use of O-(2-[18F] fluoroethyl)-L-tyrosine ([18F] FET) in neurooncology

C Stegmayr, G Stoffels, C Filss, A Heinzel… - Nuclear medicine and …, 2021 - Elsevier
The diagnostic potential of PET using the amino acid analogue O-(2-[18 F] fluoroethyl)-L-
tyrosine ([18 F] FET) in brain tumor diagnostics has been proven in many studies during the …

Analysis of 18F-FET PET for grading of recurrent gliomas: is evaluation of uptake kinetics superior to standard methods?

G Pöpperl, FW Kreth, J Herms, W Koch… - Journal of nuclear …, 2006 - Soc Nuclear Med
The aim of the present study was to evaluate whether extended analyses of O-(2-18F-
fluoroethyl)-l-tyrosine (FET) uptake kinetics provide results superior to those of standard …

The usefulness of dynamic O-(2-18F-fluoroethyl)-L-tyrosine PET in the clinical evaluation of brain tumors in children and adolescents

V Dunkl, C Cleff, G Stoffels, N Judov… - Journal of nuclear …, 2015 - Soc Nuclear Med
Experience regarding O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) PET in children and
adolescents with brain tumors is limited. Methods: Sixty-nine 18F-FET PET scans of 48 …

Influence of blood-brain barrier permeability on O-(2-18F-fluoroethyl)-L-tyrosine uptake in rat gliomas

C Stegmayr, U Bandelow, D Oliveira… - European journal of …, 2017 - Springer
Abstract Purpose O-(2-18 F-fluoroethyl)-L-tyrosine (18 F-FET) is an established tracer for the
diagnosis of brain tumors with PET. This study investigates the influence of blood-brain …

Relationship of regional cerebral blood flow and kinetic behaviour of O-(2-18F-fluoroethyl)-L-tyrosine uptake in cerebral gliomas

K Zhang, KJ Langen, I Neuner, G Stoffels… - Nuclear medicine …, 2014 - journals.lww.com
Objectives O-(2-18 F-fluoroethyl)-L-tyrosine (18 F-FET) is an established tracer for brain
tumour imaging. 18 F-FET kinetics in gliomas appear to have potential for tumour grading …

[HTML][HTML] Quantification of O-(2-[18F]fluoroethyl)-L-tyrosine kinetics in glioma

T Koopman, N Verburg, RC Schuit, PJW Pouwels… - EJNMMI research, 2018 - Springer
Background This study identified the optimal tracer kinetic model for quantification of
dynamic O-(2-[18 F] fluoroethyl)-L-tyrosine ([18 F] FET) positron emission tomography (PET) …

18F-Fluoroethyl-tyrosine uptake is correlated with amino acid transport and neovascularization in treatment-naive glioblastomas

F Liesche, M Lukas, C Preibisch, K Shi… - European journal of …, 2019 - Springer
Purpose To investigate the in vivo correlation between 18 F-fluoroethyl-tyrosine (18 F-FET)
uptake and amino acid transporter expression and vascularization in treatment-naive …