Inclusion of time-of-flight (TOF) information in PET reconstructions has been demonstrated to
improve image quality through better signal-to-noise ratios, faster convergence, better lesion …

Phantom studies have shown improved lesion detection performance with time-of-flight
(TOF) PET. In this study, we evaluate the benefit of fully 3-dimensional, TOF PET in clinical …

Time-of-flight (TOF) PET has great potential in whole-body oncologic applications, and
recent work has demonstrated qualitatively in patient studies the improvement that can be …

Objectives The last decade has seen considerable technological innovations in PET
detectors with the availability, among other advances, of time-of-flight (TOF). TOF has been …

Methods for joint activity reconstruction and attenuation reconstruction of time-of-flight (TOF)
PET data provide an effective solution to attenuation correction when no (or incomplete or …

Introduction Accurate quantification of tumour tracer uptake is essential for therapy
monitoring by sequential PET imaging. In this study we investigated to what extent a …

Time-of-flight (TOF) PET was initially introduced in the early days of PET. The TOF PET
scanners developed in the 1980s had limited sensitivity and spatial resolution, were …

Background Accuracy in the quantification of the SUV is a critical point in PET because
proper quantification of tumor uptake is essential for therapy monitoring and prognosis …

Significant improvements have made it possible to add the technology of time-of-flight (TOF)
to improve PET, particularly for oncology applications. The goals of this work were to …

A major disadvantage of 18F-FDG PET involves poor detection of small lesions and lesions
with low metabolism, caused by limited spatial resolution and relatively large image voxel …